FUT3

Gene Symbol FUT3
Entrez Gene 2525
Alt Symbol CD174, FT3B, FucT-III, LE, Les
Species Human
Gene Type protein-coding
Description fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Other Description Lewis FT|alpha-(1,3/1,4)-fucosyltransferase|blood group Lewis alpha-4-fucosyltransferase|fucosyltransferase III|galactoside 3(4)-L-fucosyltransferase
Swissprots Q99449 P21217 Q99448 B5U7V0 B5U7U9 Q32NE7
Accessions AAW34365 BAA13941 BAA13942 BAA96390 CAQ56302 CAQ68512 CAQ68513 CAQ68514 CAQ81986 CAQ81987 CAR64692 CAR64693 EAW69135 P21217 AF131913 AAD33514 AK291852 BAF84541 AK313575 BAG36347 BC074836 AAH74836 BC074837 AAH74837 BC108675 AAI08676 BM671165 DA876997 DA930897 DB200655 U27326 AAC50185 U27327 AAC50186 U27328 AAC50187 X53578 CAA37641 XM_011527865 XP_011526167 XM_011527866 XP_011526168 XM_011527867 XP_011526169 NM_000149 NP_000140 NM_001097639 NP_001091108 NM_001097640 NP_001091109 NM_001097641 NP_001091110
Function May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Tissue Specificity Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.
Top Pathways Glycosphingolipid biosynthesis - lacto and neolacto series

Blood Group Lewis a (7LE) - sc-51512 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blood Group Lewis a (7LE): sc-51512. Western blot analysis of Blood Group Lewis a expression in WiDr whole cell lysate.

Blood Group Lewis a (SPM279) - sc-52988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blood Group Lewis a (SPM279): sc-52988. Western blot analysis of Blood Group Lewis a expression in WiDr whole cell lysate under non-reducing conditions.

Blood Group Lewis a (T174) - sc-59469 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blood Group Lewis a (T174): sc-59469. Western blot analysis of Blood Group Lewis a expression in WiDr whole cell lysate.

Blood Group Lewis b (T218) - sc-59470 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blood Group Lewis b (T218): sc-59470. Western blot analysis of Blood Group Lewis b expression in COLO 320DM whole cell lysate.

Blood Group Lewis b (2-25LE) - sc-51513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Blood Group Lewis x (P12) - sc-59471 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Blood Group Lewis x (P12): sc-59471. Immunoperox-idase staining of formalin fixed, paraffin-embedded human small intestine tissue showing cytoplasmic staining of glandular cells.

Blood Group Lewis y (A70-C/C8) - sc-59472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

FucT-III/V/VI (D-17) - sc-14874 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FucT-III/V/VI (H-70) - sc-292575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

FucT-III/V/VI (I-21) - sc-14873 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
FucT-III/V/VI (I-21): sc-14873. Western blot analysis of FucT-III/V/VI expression in HL-60 whole cell lysate.

Sialyl Lewis a (121SLE) - sc-51696 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-FUT3 antibody - ab110082 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FUT3 antibody (ab110082) at 1/500 dilutionLane 1 : extracts from K562 cellsLane 2 : extracts from Jurkat cellsLane 3 : extracts from Jurkat cells with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-FUT3 antibody - ab169223 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-FUT3 antibody (ab169223) at 1 µg/mlLane 1 : FUT3 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-FUT3 antibody - ab102844 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FUT3 antibody (ab102844) at 1/100 dilution + A2058 cell lysate at 35 µg

Anti-FUT3 / CD174 Antibody (aa35-361) - LS-C66380 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FUT3 / CD174 Antibody (aa288-315, AP) - LS-C214392 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa288-315, FITC) - LS-C214396 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa288-315, APC) - LS-C214391 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa288-315, Biotin) - LS-C214395 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa288-315, Azide-free, HRP) - LS-C214397 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa288-315, PE) - LS-C214398 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody - LS-C308040 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa294-324) - LS-C321484 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody - LS-C310416 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FUT3 / CD174 Antibody (aa138-183) - LS-C313765 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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