| Gene Symbol | FUT3 |
|---|---|
| Entrez Gene | 2525 |
| Alt Symbol | CD174, FT3B, FucT-III, LE, Les |
| Species | Human |
| Gene Type | protein-coding |
| Description | fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) |
| Other Description | Lewis FT|alpha-(1,3/1,4)-fucosyltransferase|blood group Lewis alpha-4-fucosyltransferase|fucosyltransferase III|galactoside 3(4)-L-fucosyltransferase |
| Swissprots | Q99449 P21217 Q99448 B5U7V0 B5U7U9 Q32NE7 |
| Accessions | AAW34365 BAA13941 BAA13942 BAA96390 CAQ56302 CAQ68512 CAQ68513 CAQ68514 CAQ81986 CAQ81987 CAR64692 CAR64693 EAW69135 P21217 AF131913 AAD33514 AK291852 BAF84541 AK313575 BAG36347 BC074836 AAH74836 BC074837 AAH74837 BC108675 AAI08676 BM671165 DA876997 DA930897 DB200655 U27326 AAC50185 U27327 AAC50186 U27328 AAC50187 X53578 CAA37641 XM_011527865 XP_011526167 XM_011527866 XP_011526168 XM_011527867 XP_011526169 NM_000149 NP_000140 NM_001097639 NP_001091108 NM_001097640 NP_001091109 NM_001097641 NP_001091110 |
| Function | May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. |
| Tissue Specificity | Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver. |
| Top Pathways | Glycosphingolipid biosynthesis - lacto and neolacto series |
FucT-III/V/VI CRISPR/Cas9 KO Plasmid (h) - sc-401521 from Santa Cruz Biotechnology
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FucT-III/V/VI HDR Plasmid (h) - sc-401521-HDR from Santa Cruz Biotechnology
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FucT-III/V/VI Double Nickase Plasmid (h) - sc-401521-NIC from Santa Cruz Biotechnology
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FucT-III/V/VI Double Nickase Plasmid (h2) - sc-401521-NIC-2 from Santa Cruz Biotechnology
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FucT-III/V/VI CRISPR Activation Plasmid (h) - sc-401521-ACT from Santa Cruz Biotechnology
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FucT-III/V/VI CRISPR Activation Plasmid (h2) - sc-401521-ACT-2 from Santa Cruz Biotechnology
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FucT-III/V/VI Lentiviral Activation Particles (h) - sc-401521-LAC from Santa Cruz Biotechnology
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FucT-III/V/VI Lentiviral Activation Particles (h2) - sc-401521-LAC-2 from Santa Cruz Biotechnology
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FucT-III siRNA (h) - sc-40584 from Santa Cruz Biotechnology
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FucT-III shRNA Plasmid (h) - sc-40584-SH from Santa Cruz Biotechnology
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FucT-III shRNA (h) Lentiviral Particles - sc-40584-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU032681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8999 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8999 from Sigma-Aldrich
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FUT3 siRNA (Human) - CRH1670 from Cohesion Biosciences
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FUT3 - MBS8217615 from MyBioSource
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shRNA set against Human FUT3(NM_000149.3) - SHH070643 from Creative biogene
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FUT3 shRNA Plasmid (Human) - CHH1670 from Cohesion Biosciences
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FUT3 miRNA 3'UTR clone - MiUTR1H-03880 from Creative biogene
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