| Gene Symbol |
FLII
|
| Entrez Gene |
2314
|
| Alt Symbol |
FLI, FLIL, Fli1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
flightless I homolog (Drosophila)
|
| Other Description |
protein flightless-1 homolog
|
| Swissprots |
F5H407 B4DIL0 J3QLG3 Q13045
|
| Accessions |
AAC02796 EAW55653 EAW55654 EAW55655 EAW55656 Q13045 AB208864 BAD92101 AK295655 BAG58522 AK295814 BAG58632 AK297836 BAG60170 AK310400 BC001582 BC017030 BC021885 BC025300 AAH25300 BM930929 DC341570 DQ893621 ABM84547 DQ896850 ABM87849 U01184 AAC03568 XM_005256555 XP_005256612 XM_005256556 XP_005256613 XM_005256558 XP_005256615 NM_001256264 NP_001243193 NM_001256265 NP_001243194 NM_002018 NP_002009
|
| Function |
May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250, ECO:0000269|PubMed:14966289}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Strongest expression in skeletal muscle with high expression also in the heart and lung. {ECO:0000269|PubMed:9525888}.
|
![Western Blot: Flightless I Overexpression Lysate (Adult Normal) [NBP2-10791] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Flightless I.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2286_Flightless%2520I%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10791-img0001.jpg)