FLII

Gene Symbol FLII
Entrez Gene 2314
Alt Symbol FLI, FLIL, Fli1
Species Human
Gene Type protein-coding
Description flightless I homolog (Drosophila)
Other Description protein flightless-1 homolog
Swissprots F5H407 B4DIL0 J3QLG3 Q13045
Accessions AAC02796 EAW55653 EAW55654 EAW55655 EAW55656 Q13045 AB208864 BAD92101 AK295655 BAG58522 AK295814 BAG58632 AK297836 BAG60170 AK310400 BC001582 BC017030 BC021885 BC025300 AAH25300 BM930929 DC341570 DQ893621 ABM84547 DQ896850 ABM87849 U01184 AAC03568 XM_005256555 XP_005256612 XM_005256556 XP_005256613 XM_005256558 XP_005256615 NM_001256264 NP_001243193 NM_001256265 NP_001243194 NM_002018 NP_002009
Function May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling. Involved in early embryonic development (By similarity). May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation. {ECO:0000250, ECO:0000269|PubMed:14966289}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localizes to centrosomes (By similarity). {ECO:0000250}.
Tissue Specificity Strongest expression in skeletal muscle with high expression also in the heart and lung. {ECO:0000269|PubMed:9525888}.

Flightless I CRISPR/Cas9 KO Plasmid (h) - sc-401667 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I HDR Plasmid (h) - sc-401667-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I Double Nickase Plasmid (h) - sc-401667-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I Double Nickase Plasmid (h2) - sc-401667-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I CRISPR Activation Plasmid (h) - sc-401667-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I CRISPR Activation Plasmid (h2) - sc-401667-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I Lentiviral Activation Particles (h) - sc-401667-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I Lentiviral Activation Particles (h2) - sc-401667-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Flightless I siRNA (h) - sc-35386 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Flightless I shRNA Plasmid (h) - sc-35386-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Flightless I shRNA (h) Lentiviral Particles - sc-35386-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU035321 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8732 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8732 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FLII siRNA (Human) - CRH1619 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FLII - MBS8231846 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FLII (NM_002018.3) - SHH295429 from Creative biogene

Category siRNA
Species Reactivities Human

FLII shRNA Plasmid (Human) - CHH1619 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FLII miRNA 3'UTR clone - MiUTR3H-03300 from Creative biogene

Species Reactivities Human
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