| Gene Symbol |
KCNK18
|
| Entrez Gene |
338567
|
| Alt Symbol |
K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, two pore domain subfamily K, member 18
|
| Other Description |
TWIK-related individual K+ channel|TWIK-related individual potassium channel|TWIK-related spinal cord K+ channel|TWIK-related spinal cord potassium channel|potassium channel subfamily K member 18|potassium channel, subfamily K, member 18
|
| Swissprots |
Q7Z418 Q5SQQ8
|
| Accessions |
Q7Z418 AB087138 BAC78527 BC148337 AAI48338 BC152979 AAI52980 NM_181840 NP_862823
|
| Function |
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:20006580}; Multi-pass membrane protein {ECO:0000269|PubMed:20006580}.
|
| Tissue Specificity |
Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. {ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611}.
|
![Western Blot: KCNK18 Overexpression Lysate (Adult Normal) [NBL1-12181] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNK18.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5173_KCNK18%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12181-img0002.jpg)