KCNK18

Gene Symbol KCNK18
Entrez Gene 338567
Alt Symbol K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK
Species Human
Gene Type protein-coding
Description potassium channel, two pore domain subfamily K, member 18
Other Description TWIK-related individual K+ channel|TWIK-related individual potassium channel|TWIK-related spinal cord K+ channel|TWIK-related spinal cord potassium channel|potassium channel subfamily K member 18|potassium channel, subfamily K, member 18
Swissprots Q7Z418 Q5SQQ8
Accessions Q7Z418 AB087138 BAC78527 BC148337 AAI48338 BC152979 AAI52980 NM_181840 NP_862823
Function Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:20006580}; Multi-pass membrane protein {ECO:0000269|PubMed:20006580}.
Tissue Specificity Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. {ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611}.

TRESK (N-12) - sc-51237 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRESK (H-17) - sc-51235 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRESK (H-17): sc-51235. Western blot analysis of TRESK expression in non-transfected 293T: sc-117752 (A), human TRESK transfected 293T: sc-158006 (B), Hep G2 (C) and HeLa (D) whole cell lysates and mouse brain tissue extract (E).

TRESK (S-13) - sc-51239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRESK (P-19) - sc-51238 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRESK (P-19): sc-51238. Western blot analysis of TRESK expression in Hep G2 (A) and HeLa (B) whole cell lysates.

TRESK (H-92) - sc-99074 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-KCNK18/TRESK antibody - ab106411 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-KCNK18/TRESK antibody (ab106411) at 1 µg/mlLane 2 : Anti-KCNK18/TRESK antibody (ab106411) at 2 µg/mlLane 1 : Rat brain tissue lysate Lane 2 : Rat brain tissue lysate Lysates/proteins at 15 µg per lane.

Anti-KCNK18/TRESK antibody - ab113883 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab113883, at 5 µg/ml, staining KCNK18/TRESK in formalin-fixed, paraffin-embedded Human heart tissue by Immunohistochemistry.

Anti-KCNK18 / TRESK Antibody (Internal) IHC-plus™ - LS-B5066 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNK18 / TRESK antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5066 concentration 5 ug/ml.

Anti-KCNK18 / TRESK Antibody (aa168-197, Biotin) - LS-C236759 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa168-197, FITC) - LS-C236760 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa168-197, AP) - LS-C236757 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa168-197, APC) - LS-C236758 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa168-197, Azide-free, HRP) - LS-C249310 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa168-197, PE) - LS-C236762 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa167-197) - LS-C322401 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KCNK18 / TRESK Antibody (aa168-197) - LS-C165440 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
KCNK18 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

KCNK18 Antibody - NBP1-77097 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: KCNK18 Antibody [NBP1-77097] - Rat brain tissue lysate with KCNK18 antibody at (A) 1 and (B) 2 ug/mL

KCNK18 Antibody - NBP1-81570 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRESK antibody produced in rabbit - SAB3500141 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-TRESK: <B>Cat. No. SAB3500141</B>: Western blot analysis of TRESK in rat brain tissue lysate with TRESK antibody at (A) 1 and (B) 2 μg/mL.

ANTI-KCNK18 (CENTER) antibody produced in rabbit - SAB1307055 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-KCNK18 (Center): <B>Cat. No. SAB1307055</B>: KCNK18 Antibody (Center) western blot analysis in SiHa,U251,MCF-7 cell line lysates (35 μg/lane).

Anti-KCNK18 / TRESK antibody produced in rabbit - SAB2900866 from Sigma-Aldrich

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KCNK18/TRESK (N-Terminus), antibody produced in rabbit: <B>Cat. No. SAB2900866</B>: Anti-KCNK18/TRESK antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 μg/mL.

Anti-KCNK18 antibody produced in rabbit - HPA044739 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-KCNK18: <B>Cat. No. HPA044739</B>: Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in Purkinje cells.

KCNK18-Antibody-Center - AP13619c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
KCNK18 Antibody (Center) (Cat. #AP13619c) western blot analysis in SiHa,U251,MCF-7 cell line lysates (35ug/lane).This demonstrates the KCNK18 antibody detected the KCNK18 protein (arrow).

KCNK18 Antibody - middle region (OAAB09920) - OAAB09920 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

TRESK antibody - orb75337 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed and paraffin-embedded rat brain tissue at 5 ug/mL using TRESK antibody
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