KCNK18

Gene Symbol	KCNK18
Entrez Gene	338567
Alt Symbol	K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK
Species	Human
Gene Type	protein-coding
Description	potassium channel, two pore domain subfamily K, member 18
Other Description	TWIK-related individual K+ channel|TWIK-related individual potassium channel|TWIK-related spinal cord K+ channel|TWIK-related spinal cord potassium channel|potassium channel subfamily K member 18|potassium channel, subfamily K, member 18
Swissprots	Q7Z418 Q5SQQ8
Accessions	Q7Z418 AB087138 BAC78527 BC148337 AAI48338 BC152979 AAI52980 NM_181840 NP_862823
Function	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). {ECO:0000250}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:20006580}; Multi-pass membrane protein {ECO:0000269|PubMed:20006580}.
Tissue Specificity	Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. {ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KCNK18/TRESK full length protein - ab132696 from Abcam Category Protein Source Wheat germ Species Human

KCNK18/TRESK peptide - ab109923 from Abcam Category Peptide

KCNK18 / TRESK Antibody Blocking Peptide - LS-E2569 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCNK18 / TRESK Antibody Blocking Peptide - LS-E30840 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human KCNK18 Protein - H00338567-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

KCNK18 Blocking Peptide - NBP1-77097PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

KCNK18-Antibody-Center-Blocking-peptide - BP13619c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRESK Peptide - GTX85212-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

KCNK18 - H00338567-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

KCNK18 - H00338567-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

KCNK18 Control Peptide - AP30941CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRESK Peptide - 5557P from ProSci Category Peptide Species Human

KCNK18 fusion protein - Ag20514 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

KCNK18 Recombinant Protein Antigen - NBP1-81570PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCNK18 Peptide, Human - M34GP07982H from Creative Peptides Category Peptide Source Synthetic. Species Human

Potassium channel subfamily K member 18 (KCNK18), Recombinant Protein - MBS7017739 from MyBioSource Category Protein Prices $1,190.00, $2,175.00, $3,385.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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