| Gene Symbol | KCNK18 |
|---|---|
| Entrez Gene | 338567 |
| Alt Symbol | K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, two pore domain subfamily K, member 18 |
| Other Description | TWIK-related individual K+ channel|TWIK-related individual potassium channel|TWIK-related spinal cord K+ channel|TWIK-related spinal cord potassium channel|potassium channel subfamily K member 18|potassium channel, subfamily K, member 18 |
| Swissprots | Q7Z418 Q5SQQ8 |
| Accessions | Q7Z418 AB087138 BAC78527 BC148337 AAI48338 BC152979 AAI52980 NM_181840 NP_862823 |
| Function | Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:20006580}; Multi-pass membrane protein {ECO:0000269|PubMed:20006580}. |
| Tissue Specificity | Expressed specifically in dorsal root ganglion and trigeminal ganglion neurons. Detected at low levels in spinal cord. {ECO:0000269|PubMed:12754259, ECO:0000269|PubMed:15562060, ECO:0000269|PubMed:20871611}. |
TRESK CRISPR/Cas9 KO Plasmid (h) - sc-410419 from Santa Cruz Biotechnology
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TRESK HDR Plasmid (h) - sc-410419-HDR from Santa Cruz Biotechnology
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TRESK Double Nickase Plasmid (h) - sc-410419-NIC from Santa Cruz Biotechnology
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TRESK Double Nickase Plasmid (h2) - sc-410419-NIC-2 from Santa Cruz Biotechnology
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TRESK CRISPR Activation Plasmid (h) - sc-410419-ACT from Santa Cruz Biotechnology
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TRESK CRISPR Activation Plasmid (h2) - sc-410419-ACT-2 from Santa Cruz Biotechnology
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TRESK Lentiviral Activation Particles (h) - sc-410419-LAC from Santa Cruz Biotechnology
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TRESK Lentiviral Activation Particles (h2) - sc-410419-LAC-2 from Santa Cruz Biotechnology
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TRESK siRNA (h) - sc-61709 from Santa Cruz Biotechnology
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TRESK shRNA Plasmid (h) - sc-61709-SH from Santa Cruz Biotechnology
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TRESK shRNA (h) Lentiviral Particles - sc-61709-V from Santa Cruz Biotechnology
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KCNK18 RNAi - H00338567-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10969 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10969 from Sigma-Aldrich
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KCNK18 siRNA (Human) - CRJ7242 from Cohesion Biosciences
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shRNA set against Human Kcnk18 (NM_181840.1) - SHH323435 from Creative biogene
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shRNA set against Human KCNK18(NM_181840.1) - SHL190182 from Creative biogene
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Human KCNK18 siRNA - orb277743 from Biorbyt
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KCNK18 shRNA Plasmid (Human) - CHJ7242 from Cohesion Biosciences
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KCNK18 miRNA 3'UTR clone - MiUTR1H-05144 from Creative biogene
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