| Gene Symbol |
WDR34
|
| Entrez Gene |
89891
|
| Alt Symbol |
DIC5, FAP133, SRTD11, bA216B9.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain 34
|
| Other Description |
WD repeat-containing protein 34
|
| Swissprots |
Q9BV46 Q96EX3 Q5VXV4
|
| Accessions |
EAW87814 EAW87815 EAW87816 Q96EX3 AK302098 BAG63480 AL555205 BC001614 AAH01614 BC011874 AAH11874 BG177634 BI910783 XM_011519179 XP_011517481 NM_052844 NP_443076
|
| Function |
Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. {ECO:0000269|PubMed:19521662, ECO:0000269|PubMed:24183449}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:19521662}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19521662}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19521662}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in several cell lines (at protein level). {ECO:0000269|PubMed:19521662}.
|
![Western Blot: WDR34 Overexpression Lysate (Adult Normal) [NBP2-05859] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for WDR34.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10580_WDR34%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05859-img0001.jpg)