WDR34

Gene Symbol WDR34
Entrez Gene 89891
Alt Symbol DIC5, FAP133, SRTD11, bA216B9.3
Species Human
Gene Type protein-coding
Description WD repeat domain 34
Other Description WD repeat-containing protein 34
Swissprots Q9BV46 Q96EX3 Q5VXV4
Accessions EAW87814 EAW87815 EAW87816 Q96EX3 AK302098 BAG63480 AL555205 BC001614 AAH01614 BC011874 AAH11874 BG177634 BI910783 XM_011519179 XP_011517481 NM_052844 NP_443076
Function Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. {ECO:0000269|PubMed:19521662, ECO:0000269|PubMed:24183449}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:19521662}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19521662}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19521662}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining. {ECO:0000250}.
Tissue Specificity Expressed in several cell lines (at protein level). {ECO:0000269|PubMed:19521662}.

WDR34 (C-20) - sc-244627 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-WDR34 antibody - ab81030 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab81030 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab81030, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-WDR34 antibody - ab170657 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-WDR34 antibody (ab170657) at 1/100 dilution + Sk-Br-3 cell lysate at 35 µg

Anti-WDR34 antibody - ab168175 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-WDR34 antibody (ab168175) at 1 µg/mlLane 1 : WDR34 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG HRP at 1/2500 dilution

Anti-WDR34 Antibody (aa305-334, AP) - LS-C242696 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa305-334, APC) - LS-C242699 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa305-334, Biotin) - LS-C242698 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa305-334, FITC) - LS-C242700 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa305-334, Azide-free, HRP) - LS-C247244 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa305-334, PE) - LS-C242701 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa304-334) - LS-C326328 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 Antibody (aa434-483) - LS-C82534 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Fetal brain lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-WDR34 Antibody (aa305-334) - LS-C160581 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
WDR34 Antibody western blot of SK-BR-3 cell line lysates (35 ug/lane). The WDR34 antibody detected the WDR34 protein (arrow).

WDR34 Antibody - NBP1-88805 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: WDR34 Antibody [NBP1-88805] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.

WDR34 Antibody - NBP1-55268 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

WDR34 Antibody - NBP1-88806 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WDR34 Antibody - H00089891-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: WDR34 Antibody [H00089891-B01P] - Analysis of WDR34 expression in transfected 293T cell line by WDR34 polyclonal antibody. Lane 1: WDR34 transfected lysate(46.09 KDa). Lane 2: Non-transfected lysate.

WDR34 Antibody - H00089891-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: WDR34 Antibody [H00089891-B01] - analysis of WDR34 expression in transfected 293T cell line by WDR34 MaxPab polyclonal antibody. Lane 1: WDR34 transfected lysate (46.09 KDa). Lane 2: Non-transfected lysate.

Anti-WDR34 antibody produced in rabbit - SAB2102699 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR34 antibody produced in rabbit - HPA041091 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WDR34: <B>Cat. No. HPA041091</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.

Anti-WDR34 antibody produced in mouse - SAB1401931 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Polyclonal Anti-WDR34, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1401931</B>: Antibody concentration: 0.1 - 5.0 μg/mL. Specific band of ~46.09 kDa using WDR34 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-WDR34 antibody produced in rabbit - HPA040764 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-WDR34: <B>Cat. No. HPA040764</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in glandular cells.

WDR34 antibody - C-terminal region (ARP48430_P050) - ARP48430_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WDR34-Antibody-Center - AP12421c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
WDR34 Antibody (Center) (Cat. #AP12421c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the WDR34 antibody detected the WDR34 protein (arrow).

WDR34 Antibody - middle region (OAAB08687) - OAAB08687 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
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