| Gene Symbol | SEMA5A |
|---|---|
| Entrez Gene | 9037 |
| Alt Symbol | SEMAF, semF |
| Species | Human |
| Gene Type | protein-coding |
| Description | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| Other Description | sema F|semaphorin 5A|semaphorin F|semaphorin-5A|semaphorin-F |
| Swissprots | D3DTC6 O60408 Q13591 Q1RLL9 |
| Accessions | AAC14668 EAX08078 EAX08079 Q13591 AF009314 AF056434 AK022877 AK293441 BAG56944 AK307587 BC115696 AAI15697 BM669539 CX788776 DA336109 KJ534937 AHW56577 KJ535077 AHW56716 U52840 AAC09473 XM_006714506 XP_006714569 XM_006714507 XP_006714570 XM_011514155 XP_011512457 XM_011514156 XP_011512458 XM_011514157 XP_011512459 XM_011514158 XP_011512460 XM_011514159 XP_011512461 NM_003966 NP_003957 |
| Function | Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Top Pathways | Axon guidance |