SEMA5A

Gene Symbol	SEMA5A
Entrez Gene	9037
Alt Symbol	SEMAF, semF
Species	Human
Gene Type	protein-coding
Description	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Other Description	sema F|semaphorin 5A|semaphorin F|semaphorin-5A|semaphorin-F
Swissprots	D3DTC6 O60408 Q13591 Q1RLL9
Accessions	AAC14668 EAX08078 EAX08079 Q13591 AF009314 AF056434 AK022877 AK293441 BAG56944 AK307587 BC115696 AAI15697 BM669539 CX788776 DA336109 KJ534937 AHW56577 KJ535077 AHW56716 U52840 AAC09473 XM_006714506 XP_006714569 XM_006714507 XP_006714570 XM_011514155 XP_011512457 XM_011514156 XP_011512458 XM_011514157 XP_011512459 XM_011514158 XP_011512460 XM_011514159 XP_011512461 NM_003966 NP_003957
Function	Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Semaphorin 5A protein fragment - ab151658 from Abcam Category Protein Source HEK 293 cells Species Human

Human Semaphorin 5A protein fragment - ab152943 from Abcam Category Protein Source Wheat germ Species Human

Mouse Semaphorin 5A peptide - ab41482 from Abcam Category Peptide

Mouse Semaphorin 5A peptide - ab41483 from Abcam Category Peptide

SEMA5A / Semaphorin 5A Antibody Blocking Peptide - LS-E26141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SEMA5A / Semaphorin 5A Antibody Blocking Peptide - LS-E7023 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SEMA5A / Semaphorin 5A Antibody Blocking Peptide - LS-E7024 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SEMA5A / Semaphorin 5A Antibody Blocking Peptide - LS-E7025 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Semaphorin 5A Protein - H00009037-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Semaphorin-5A-Antibody-Blocking-peptide - BP2712c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

M-Sema5a-Antibody-Blocking-peptide - BP2712b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

M-Sema5a-Antibody-N-term-Blocking-peptide - BP2712a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Semastatin-5A2 - SP3136b from Abgent, a WuXi AppTec company Category Peptide Prices $144.00 Sizes 5 mg

Semastatin-5A2 - SP3136a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg

Semaphorin 5A blocking peptide - GTX89289-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Recombinant Human Semaphorin 5A Fc Chimera, CF - 5896-S5-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human SEMA5A Fc tag protein - orb84511 from Biorbyt Category Protein Prices $417.00, $748.00 Sizes 20 μg, 50 μg Source Human Species Human

Human Semaphorin 5A protein - orb49636 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Semaphorin 5A Peptide - AC21-0971-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SEMA5A - H00009037-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SEMA5A - H00009037-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Semaphorin-5A, Human, Recombinant - 19-C499 from ARP American Research Products Category Protein Prices $149.00 Sizes 10 µg Source HEK293 Species Human

Semaphorin 5A Peptide - 46-349P from ProSci Category Peptide Species Human

SEMA5A fusion protein - ag16346 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SEMA5A Protein - BP001095-C499 from Syd Labs Category Protein Prices $154.00, $462.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source HEK 293-derived. Species Human

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