SEMA5A

Gene Symbol SEMA5A
Entrez Gene 9037
Alt Symbol SEMAF, semF
Species Human
Gene Type protein-coding
Description sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
Other Description sema F|semaphorin 5A|semaphorin F|semaphorin-5A|semaphorin-F
Swissprots D3DTC6 O60408 Q13591 Q1RLL9
Accessions AAC14668 EAX08078 EAX08079 Q13591 AF009314 AF056434 AK022877 AK293441 BAG56944 AK307587 BC115696 AAI15697 BM669539 CX788776 DA336109 KJ534937 AHW56577 KJ535077 AHW56716 U52840 AAC09473 XM_006714506 XP_006714569 XM_006714507 XP_006714570 XM_011514155 XP_011512457 XM_011514156 XP_011512458 XM_011514157 XP_011512459 XM_011514158 XP_011512460 XM_011514159 XP_011512461 NM_003966 NP_003957
Function Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Top Pathways Axon guidance

SEMA5A CRISPR/Cas9 KO Plasmid (h) - sc-407748 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A HDR Plasmid (h) - sc-407748-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A Double Nickase Plasmid (h) - sc-407748-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A Double Nickase Plasmid (h2) - sc-407748-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A CRISPR Activation Plasmid (h) - sc-407748-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A CRISPR Activation Plasmid (h2) - sc-407748-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A Lentiviral Activation Particles (h) - sc-407748-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A Lentiviral Activation Particles (h2) - sc-407748-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SEMA5A siRNA (h) - sc-63000 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SEMA5A shRNA Plasmid (h) - sc-63000-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SEMA5A shRNA (h) Lentiviral Particles - sc-63000-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Semaphorin 5A RNAi - H00009037-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU039401 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19076 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19076 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SEMA5A siRNA (Human) - CRH5960 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SEMA5A - MBS8216435 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Sema5a (NM_003966.2) - SHH404340 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SEMA5A(NM_003966.2) - SHR214328 from Creative biogene

Category siRNA
Species Reactivities Human

Human SEMA5A siRNA - orb266462 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SEMA5A shRNA Plasmid (Human) - CHH5960 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SEMA5A miRNA 3'UTR clone - MiUTR1H-09256 from Creative biogene

Species Reactivities Human
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