HORMAD2

Gene Symbol	HORMAD2
Entrez Gene	150280
Alt Symbol	CT46.2
Species	Human
Gene Type	protein-coding
Description	HORMA domain containing 2
Other Description	HORMA domain-containing protein 2
Swissprots	Q8N7B1 Q8NHR2 B5MEB2
Accessions	CAN59692 EAW59859 EAW59860 Q8N7B1 AK098703 BAC05388 BC030013 AAH30013 CR456341 CAG30227 CU013052 CAK54483 CU013340 CAK54782 XM_006724147 XP_006724210 XM_011529913 XP_011528215 XM_011529914 XP_011528216 XM_011529915 XP_011528217 XM_011529916 XP_011528218 XM_011529917 XP_011528219 XM_011529918 XP_011528220 XM_011529919 XP_011528221 NM_152510 NP_689723
Function	Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22893617}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney. {ECO:0000269|PubMed:15999985, ECO:0000269|PubMed:22893617}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HORMAD2 293T Cell Transient Overexpression Lysate(Denatured) - H00150280-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HORMAD2 overexpression lysate - LY407512 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HORMAD2 293 Cell Lysate - 404273 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

HORMAD2 Overexpression Lysate (Native) - NBL1-11663 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

HORMAD2 Over-expression Lysate Product - GWB-40775E from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

HORMAD2 Overexpression Lysate (Denatured) - H00150280-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human HORMAD2 Knockdown Stable Cell Line - CSC-DC007181 from Creative biogene Category Cell Line Species Human

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