HORMAD2

Gene Symbol	HORMAD2
Entrez Gene	150280
Alt Symbol	CT46.2
Species	Human
Gene Type	protein-coding
Description	HORMA domain containing 2
Other Description	HORMA domain-containing protein 2
Swissprots	Q8N7B1 Q8NHR2 B5MEB2
Accessions	CAN59692 EAW59859 EAW59860 Q8N7B1 AK098703 BAC05388 BC030013 AAH30013 CR456341 CAG30227 CU013052 CAK54483 CU013340 CAK54782 XM_006724147 XP_006724210 XM_011529913 XP_011528215 XM_011529914 XP_011528216 XM_011529915 XP_011528217 XM_011529916 XP_011528218 XM_011529917 XP_011528219 XM_011529918 XP_011528220 XM_011529919 XP_011528221 NM_152510 NP_689723
Function	Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:22893617}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney. {ECO:0000269|PubMed:15999985, ECO:0000269|PubMed:22893617}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HORMAD2 full length protein - ab127143 from Abcam Category Protein Source E. coli Species Human

HORMAD2 Antibody Blocking Peptide - LS-E19112 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HORMAD2 Antibody Blocking Peptide - LS-E19113 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HORMAD2 Recombinant Protein - H00150280-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

HORMAD2 Blocking Peptide - 33R-10259 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HORMAD2 Blocking Peptide - 33R-9626 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HORMAD2 - H00150280-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HORMAD2 - H00150280-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HORMAD2 fusion protein - ag19739 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

HORMAD2 fusion protein - Ag19753 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human HORMAD2 - HORMAD2-1507H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human HORMA domain-containing protein 2(HORMAD2) - CSB-YP836683HU CSB-EP836683HU CSB-BP836683HU CSB-MP836683HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

HORMAD2 - TP305453 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HORMAD2 Recombinant Protein Antigen - NBP1-82724PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HORMAD2 Peptide, Human - M34GP07181H from Creative Peptides Category Peptide Source Synthetic. Species Human

HORMA domain-containing protein 2 (HORMAD2), Recombinant Protein - MBS1339291 from MyBioSource Category Protein Prices $1,065.00, $1,065.00, $1,295.00, $1,295.00, $1,665.00, $1,665.00, $2,130.00, $2,130.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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