| Gene Symbol | HORMAD2 |
|---|---|
| Entrez Gene | 150280 |
| Alt Symbol | CT46.2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | HORMA domain containing 2 |
| Other Description | HORMA domain-containing protein 2 |
| Swissprots | Q8N7B1 Q8NHR2 B5MEB2 |
| Accessions | CAN59692 EAW59859 EAW59860 Q8N7B1 AK098703 BAC05388 BC030013 AAH30013 CR456341 CAG30227 CU013052 CAK54483 CU013340 CAK54782 XM_006724147 XP_006724210 XM_011529913 XP_011528215 XM_011529914 XP_011528216 XM_011529915 XP_011528217 XM_011529916 XP_011528218 XM_011529917 XP_011528219 XM_011529918 XP_011528220 XM_011529919 XP_011528221 NM_152510 NP_689723 |
| Function | Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:22893617}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). {ECO:0000250}. |
| Tissue Specificity | Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney. {ECO:0000269|PubMed:15999985, ECO:0000269|PubMed:22893617}. |
HORMAD2 CRISPR/Cas9 KO Plasmid (h) - sc-405625 from Santa Cruz Biotechnology
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HORMAD2 HDR Plasmid (h) - sc-405625-HDR from Santa Cruz Biotechnology
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HORMAD2 Double Nickase Plasmid (h) - sc-405625-NIC from Santa Cruz Biotechnology
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HORMAD2 Double Nickase Plasmid (h2) - sc-405625-NIC-2 from Santa Cruz Biotechnology
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HORMAD2 CRISPR Activation Plasmid (h) - sc-405625-ACT from Santa Cruz Biotechnology
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HORMAD2 CRISPR Activation Plasmid (h2) - sc-405625-ACT-2 from Santa Cruz Biotechnology
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HORMAD2 Lentiviral Activation Particles (h) - sc-405625-LAC from Santa Cruz Biotechnology
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HORMAD2 Lentiviral Activation Particles (h2) - sc-405625-LAC-2 from Santa Cruz Biotechnology
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HORMAD2 siRNA (h) - sc-75275 from Santa Cruz Biotechnology
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HORMAD2 shRNA Plasmid (h) - sc-75275-SH from Santa Cruz Biotechnology
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HORMAD2 shRNA (h) Lentiviral Particles - sc-75275-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU085391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10226 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10226 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07146 from Sigma-Aldrich
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HORMAD2 siRNA (Human) - CRJ5649 from Cohesion Biosciences
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HORMAD2 - MBS8238074 from MyBioSource
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shRNA set against Human HORMAD2 (NM_152510.2) - SHH314057 from Creative biogene
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shRNA set against Human HORMAD2(NM_152510.2) - SHH128207 from Creative biogene
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Human HORMAD2 siRNA - orb276150 from Biorbyt
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HORMAD2 shRNA Plasmid (Human) - CHJ5649 from Cohesion Biosciences
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HORMAD2 miRNA 3'UTR clone - MiUTR1H-04647 from Creative biogene
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