HORMAD2

Gene Symbol	HORMAD2
Entrez Gene	150280
Alt Symbol	CT46.2
Species	Human
Gene Type	protein-coding
Description	HORMA domain containing 2
Other Description	HORMA domain-containing protein 2
Swissprots	Q8N7B1 Q8NHR2 B5MEB2
Accessions	CAN59692 EAW59859 EAW59860 Q8N7B1 AK098703 BAC05388 BC030013 AAH30013 CR456341 CAG30227 CU013052 CAK54483 CU013340 CAK54782 XM_006724147 XP_006724210 XM_011529913 XP_011528215 XM_011529914 XP_011528216 XM_011529915 XP_011528217 XM_011529916 XP_011528218 XM_011529917 XP_011528219 XM_011529918 XP_011528220 XM_011529919 XP_011528221 NM_152510 NP_689723
Function	Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex body formation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:22893617}. Chromosome {ECO:0000250}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cell carcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney. {ECO:0000269\|PubMed:15999985, ECO:0000269\|PubMed:22893617}.

HORMAD2 (C-18) - sc-82192 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

HORMAD2 (G-18) - sc-82193 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

HORMAD2 (H-88) - sc-366058 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

HORMAD2 (S-16) - sc-82195 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-HORMAD2 antibody - ab106256 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-HORMAD2 antibody (ab106256) at 1/500 dilution + C6 cell lysate

Anti-HORMAD2 antibody - ab89961 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-HORMAD2 antibody (ab89961) at 1 µg/ml + HT1080 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-HORMAD2 antibody - ab168241 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-HORMAD2 antibody (ab168241) at 1/500 dilutionLane 1 : HORMAD2 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-HORMAD2 Antibody (clone 2E2) - LS-C338428 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2E2

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY HORMAD2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HORMAD2.

Anti-HORMAD2 Antibody (clone 3E4) - LS-C338426 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3E4

Anti-HORMAD2 Antibody (aa107-156) - LS-C111459 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

HORMAD2 antibody LS-C111459 Western blot of Placenta lysate.

Anti-HORMAD2 Antibody (aa35-84) - LS-C111458 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

HORMAD2 antibody LS-C111458 Western blot of HT1080 cell lysate.

HORMAD2 Antibody - NBP1-82724 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: HORMAD2 Antibody [NBP1-82724] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

HORMAD2 Antibody - NBP1-52868 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: HORMAD2 Antibody [NBP1-52868] - Human Placenta lysate, concentration 0.2-1 ug/ml.

HORMAD2 Antibody - H00150280-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot analysis of HORMAD2 expression in transfected 293T cell line by HORMAD2 MaxPab polyclonal antibody. Lane 1: HORMAD2 transfected lysate (33.77 KDa). Lane 2: Non-transfected lysate.

HORMAD2 Polyclonal Antibody - bs-9071R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-HORMAD2, (N-terminal) antibody produced in rabbit - SAB2103737 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-HORMAD2, antibody produced in rabbit: <B>Cat. No. SAB2103737</B>: Immunoblotting analysis of HORMAD2 in HT1080 cell lysate with HORMAD2 anitbody at 1 μg/mL.

Anti-HORMAD2 antibody produced in rabbit - SAB2104373 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-HORMAD2, antibody produced in rabbit: <B>Cat. No. SAB2104373</B>: Immunoblotting analysis of HORMAD2 in placenta tissue lysate with HORMAD2 anitbody at 1 μg/mL.

Anti-HORMAD2 antibody produced in rabbit - HPA003074 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-HORMAD2: <B>Cat. No. HPA003074</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human cerebral cortex shows distinct positivity in neuropil.

HORMAD2 antibody - N-terminal region (ARP53007_P050) - ARP53007_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

HORMAD2 antibody - middle region (ARP53008_P050) - ARP53008_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

HORMAD2 antibody, Internal - GTX45649 from GeneTex

Prices	$319.00
Sizes	50 μg
Host	Rabbit
Clonality	Polyclonal

Anti-HORMAD2 antibody, Internal used in Western blot. GTX45649

HORMAD2 antibody, N-term - GTX45650 from GeneTex

Prices	$319.00
Sizes	50 μg
Host	Rabbit
Clonality	Polyclonal

Anti-HORMAD2 antibody, N-term used in Western blot. GTX45650

HORMAD2 antibody - orb77771 from Biorbyt

Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed paraffin embedded fetal testis staining using HORMAD2 antibody

HORMAD2 antibody - 70R-35619 from Fitzgerald

Host	Rabbit
Clonality	Polyclonal

HORMAD2 antibody - 70R-3645 from Fitzgerald

Prices	$345.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

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