| Gene Symbol | PRKCD |
|---|---|
| Entrez Gene | 5580 |
| Alt Symbol | ALPS3, CVID9, MAY1, PKCD, nPKC-delta |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, delta |
| Other Description | protein kinase C delta VIII|protein kinase C delta type|tyrosine-protein kinase PRKCD |
| Swissprots | B0KZ81 Q86XJ6 Q05655 Q15144 B2R834 |
| Accessions | CAV30705 EAW65279 EAW65280 Q05655 AK130150 AK131548 AK294272 BAG57562 AK313216 BAG36031 AW293041 BC043350 AAH43350 BC127261 BE048101 CD369320 D10495 BAA01381 DQ516383 ABF68960 L07860 AAA03176 L07861 AAA03175 Z22521 CAA80249 XM_006713257 XP_006713320 XM_006713258 XP_006713321 XM_006713259 XP_006713322 XR_940474 NM_006254 NP_006245 NM_212539 NP_997704 |
| Function | Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self- antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage- |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell membrane; Peripheral membrane protein. |
| Top Pathways | Neurotrophin signaling pathway, Tight junction, Fc gamma R-mediated phagocytosis, Type II diabetes mellitus, Chemokine signaling pathway |