PRKCD

Gene Symbol	PRKCD
Entrez Gene	5580
Alt Symbol	ALPS3, CVID9, MAY1, PKCD, nPKC-delta
Species	Human
Gene Type	protein-coding
Description	protein kinase C, delta
Other Description	protein kinase C delta VIII|protein kinase C delta type|tyrosine-protein kinase PRKCD
Swissprots	B0KZ81 Q86XJ6 Q05655 Q15144 B2R834
Accessions	CAV30705 EAW65279 EAW65280 Q05655 AK130150 AK131548 AK294272 BAG57562 AK313216 BAG36031 AW293041 BC043350 AAH43350 BC127261 BE048101 CD369320 D10495 BAA01381 DQ516383 ABF68960 L07860 AAA03176 L07861 AAA03175 Z22521 CAA80249 XM_006713257 XP_006713320 XM_006713258 XP_006713321 XM_006713259 XP_006713322 XR_940474 NM_006254 NP_006245 NM_212539 NP_997704
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self- antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell membrane; Peripheral membrane protein.
Top Pathways	Neurotrophin signaling pathway, Tight junction, Fc gamma R-mediated phagocytosis, Type II diabetes mellitus, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PKC δ siRNA (h) - sc-36253 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC δ shRNA Plasmid (h) - sc-36253-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC δ shRNA (h) Lentiviral Particles - sc-36253-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC δ siRNA (h2) - sc-44229 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC δ shRNA Plasmid (h2) - sc-44229-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC δ shRNA (h2) Lentiviral Particles - sc-44229-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC delta RNAi - H00005580-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

PKC delta RNAi - H00005580-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU067061 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1824 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1826 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1825 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1572 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1572 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1133 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12094 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr12094

PRKCD siRNA (Human) - CRH3750 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PKC delta RNAi - H00005580-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human PRKCD (NM_006254.3) - SHH382808 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PRKCD(NM_006254.3) - SHR140316 from Creative biogene Category siRNA Species Reactivities Human

Human PRKCD siRNA - orb264252 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

PRKCD shRNA Plasmid (Human) - CHH3750 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PRKCD miRNA 3'UTR clone - MiUTR3H-01936 from Creative biogene Species Reactivities Human

PRKCD miRNA 3'UTR clone - MiUTR3H-01937 from Creative biogene Species Reactivities Human

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