PRKCD

Gene Symbol PRKCD
Entrez Gene 5580
Alt Symbol ALPS3, CVID9, MAY1, PKCD, nPKC-delta
Species Human
Gene Type protein-coding
Description protein kinase C, delta
Other Description protein kinase C delta VIII|protein kinase C delta type|tyrosine-protein kinase PRKCD
Swissprots B0KZ81 Q86XJ6 Q05655 Q15144 B2R834
Accessions CAV30705 EAW65279 EAW65280 Q05655 AK130150 AK131548 AK294272 BAG57562 AK313216 BAG36031 AW293041 BC043350 AAH43350 BC127261 BE048101 CD369320 D10495 BAA01381 DQ516383 ABF68960 L07860 AAA03176 L07861 AAA03175 Z22521 CAA80249 XM_006713257 XP_006713320 XM_006713258 XP_006713321 XM_006713259 XP_006713322 XR_940474 NM_006254 NP_006245 NM_212539 NP_997704
Function Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self- antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-
Subcellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell membrane; Peripheral membrane protein.
Top Pathways Neurotrophin signaling pathway, Tight junction, Fc gamma R-mediated phagocytosis, Type II diabetes mellitus, Chemokine signaling pathway

Phospho-PKCδ (Ser359) (D2X1P) Rabbit mAb - 14787 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2X1P
Western blot analysis of various cells and tissues, untreated (-) or λ phosphatase-treated (+), using Phospho-PKCδ (Ser359) (D2X1P) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Phospho-PKCdelta (Tyr311) Antibody - 2055 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from untreated or PMA-treated U-937 and Raw264.7 cells, using phospho-PKCdelta (Tyr311) Antibody.

Phospho-PKCδ (Thr505) Antibody - 9374 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U-937 cells, untreated or TPA treated (0.2 µM), using Phospho-PKCδ (Thr505) Antibody.

Phospho-PKCδ/θ (Ser643/676) Antibody - 9376 from Cell Signaling Technology

Prices $109.00, $287.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from U-937 cells, untreated or TPA-treated (0.2 µM), using Phospho-PKCdelta/theta (Ser643/676) Antibody.

PKCδ Antibody - 2058 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of Baculovirus expressed PKC isoforms, demonstrating the isoform-specificity of PKCδ Antibody.

PKCδ (D10E2) Rabbit mAb - 9616 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10E2
Western blot analysis of extracts from various cell lines using PKCδ (D10E2) Rabbit mAb.

PKC δ (C-17) - sc-213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKC δ (C-17): sc-213-G. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic staining of glandular cells and endothelial cells.

PKC δ (C-20) - sc-937 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PKC δ (C-20)-G: sc-937-G. Western blot analysis of PKC δ expression in A-431 whole cell lysate.

p-PKC δ (Thr 507) - sc-11770 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot detection of PKC δ phosphorylation using untreated (A,C) and PMA-treated (B,D) HeLa cells. Blots were probed with p-PKC δ (Thr 507)-R: sc-11770-R (A,B) and PKC δ (C-20)-G: sc-937-G (C,D).

p-PKC δ (Tyr 187) - sc-18363 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-PKC δ (Tyr 155) - sc-18367 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-PKC δ (Tyr 155): sc-18367. Immunofluorescence staining of methanol-fixed PMA-induced HeLa cells showing cytoplasmic localization.

p-PKC δ (Tyr 332) - sc-18365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of PKC phosphorylation in untreated (A,D), pervanadate treated (B,E) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C,F) A-431 whole cell lysates. Antibodies tested include p-PKC (Tyr 332)-R: sc-18365-R (A,B,C) and PKC (C-20): sc-937 (D,E,F).

p-PKC δ (Tyr 52) - sc-18362 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of PKC phosphorylation in untreated (A,D), pervanadate treated (B,E) and pervanadate and lambda protein phosphatase (sc-200312A) treated (C,F) A-431 whole cell lysates. Antibodies tested include p-PKC (Tyr 52)-R: sc-18362-R (A,B,C) and PKC (C-20): sc-937 (D,E,F).

p-PKC δ (Tyr 565) - sc-18372 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Western blot analysis of PKC δ phosphorylation in untreated (A,D), serum starved and serum treated (B,E) and serum starved, serum treated and lambda protein phosphatase (sc-200312A) treated (C,F) HeLa whole cell lysates. Antibodies tested include p-PKC δ (Tyr 565)-R: sc-18372-R (A,B,C) and PKC δ (C-20): sc-937 (D,E,F).

p-PKC δ (Tyr 525) - sc-18368 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PKC delta (phospho S299) antibody [EPNCI119] - ab133456 from Abcam

Prices $99.00, $381.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPNCI119
All lanes : Anti-PKC delta (phospho S299) antibody [EPNCI119] (ab133456) at 1/1000 dilutionLane 1 : MCF-7 cell lysateLane 2 : MCF-7 cell lysate treated with Caylculin ALysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit IgG at 1/2000 dilution

Anti-PKC delta (phospho S645) antibody - ab47773 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human breast carcinoma stained with ab47773 at 1/50 dilution. Right hand image shows tissue treated with the immunogenic phospopeptide, whereas the left hand image is untreated.

Anti-PKC delta (phospho T505) antibody - ab60992 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKC delta (phospho T505) antibody (ab60992) at 1/500 dilutionLane 1 : Extracts from NIH/3T3cells, treated with UV (15mins).Lane 2 : Extracts from NIH/3T3cells, treated with UV (15mins) with immunizing phosphopeptide.

Anti-PKC delta (phospho T507) antibody [EPR1485Y] - ab53295 from Abcam

Prices $99.00, $313.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1485Y
All lanes : Anti-PKC delta (phospho T507) antibody [EPR1485Y] (ab53295) at 1/500 dilutionLane 1 : U937 cell lysateLane 2 : U937 cell lysate treated with TPALysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-PKC delta (phospho Y311) antibody [EPR2609Y] - ab76181 from Abcam

Prices $99.00, $368.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2609Y
Immunohistochemical analysis of paraffin-embedded human urinary bladder carcinoma with ab76181 at 1/100 dilution.

Anti-PKC delta (phospho Y313) antibody - ab182644 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKC delta (phospho Y313) antibody (ab182644) at 1/500 dilutionLane 1 : HepG2 cell lysateLane 2 : HepG2 cell lysate treated with the antigen-specific peptide.

Anti-PKC delta (phospho Y313) antibody - ab195952 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PKC delta (phospho Y313) antibody (ab195952) at 1/500 dilutionLane 1 : HepG2 whole cell lysate with antigen-specific peptideLane 2 : HepG2 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-PKC delta (phospho Y313) antibody - ab62202 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab62202 at 1/50 dilution. Right hand panel was treated with immunising phosphopeptide.

Anti-PKC delta (phospho Y52) antibody - ab74007 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ab74007, at 1/50 dilution, in the presence (right panel) or absence (left panel) of the immunising phophopeptide.

Anti-PKC delta (phospho Y64) antibody - ab138666 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PKC delta (phospho Y64) antibody (ab138666) at 1/500 dilution + HepG2 cells (treated with PMA at 125ng/ml for 30 minutes) at 30 µg
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