PRKCD

Gene Symbol	PRKCD
Entrez Gene	5580
Alt Symbol	ALPS3, CVID9, MAY1, PKCD, nPKC-delta
Species	Human
Gene Type	protein-coding
Description	protein kinase C, delta
Other Description	protein kinase C delta VIII|protein kinase C delta type|tyrosine-protein kinase PRKCD
Swissprots	B0KZ81 Q86XJ6 Q05655 Q15144 B2R834
Accessions	CAV30705 EAW65279 EAW65280 Q05655 AK130150 AK131548 AK294272 BAG57562 AK313216 BAG36031 AW293041 BC043350 AAH43350 BC127261 BE048101 CD369320 D10495 BAA01381 DQ516383 ABF68960 L07860 AAA03176 L07861 AAA03175 Z22521 CAA80249 XM_006713257 XP_006713320 XM_006713258 XP_006713321 XM_006713259 XP_006713322 XR_940474 NM_006254 NP_006245 NM_212539 NP_997704
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self- antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell membrane; Peripheral membrane protein.
Top Pathways	Neurotrophin signaling pathway, Tight junction, Fc gamma R-mediated phagocytosis, Type II diabetes mellitus, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PKC delta full length protein - ab60844 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human PKC delta full length protein - ab159199 from Abcam Category Protein Source Wheat germ Species Human

Human PKC delta peptide - ab97364 from Abcam Category Peptide

Human PKC delta protein fragment - ab159200 from Abcam Category Protein Source Wheat germ Species Human

PKC delta full length protein - ab27714 from Abcam Category Protein Source Baculovirus

PRKCD / PKC-Delta Antibody Blocking Peptide - LS-E3448 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PRKCD / PKC-Delta Antibody Blocking Peptide - LS-E8608 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PKC delta Partial Recombinant Protein - H00005580-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PKC delta Recombinant Protein - H00005580-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human PKC delta Protein - P4222 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Source Insect Species Human

PKC delta Recombinant Protein - P4756 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant PKC delta Protein - NBP1-99470 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

PKC delta Peptide - P2105 from Novus Biologicals Category Peptide Species Human

PKC-delta-Antibody-N-term-Blocking-Peptide - BP7018a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKC delta (Active) recombinant protein - GTX65211 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active PKC delta, CF - 4585-KS-010 from R&D Systems Category Protein

PKC-d Protein (OPPA01179) - OPPA01179 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Sf9 Insect Cells

PRKCD peptide - orb217797 from Biorbyt Category Peptide Prices $306.00, $519.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

PRKCD peptide - orb219158 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Monkey

PRKCD - H00005580-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PRKCD - H00005580-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PRKCD - H00005580-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKCD - H00005580-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKCD - P4222 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PRKCD - P4756 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

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