| Gene Symbol |
PLCB1
|
| Entrez Gene |
23236
|
| Alt Symbol |
EIEE12, PI-PLC, PLC-154, PLC-I, PLC154, PLCB1A, PLCB1B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, beta 1 (phosphoinositide-specific)
|
| Other Description |
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1|PLC-beta-1|inositoltrisphosphohydrolase|monophosphatidylinositol phosphodiesterase|phosphoinositidase C|phospholipase C-I|triphosphoinositide phosphodiesterase
|
| Swissprots |
Q9NTH4 Q9H8H5 Q5TGC9 Q8IV93 Q17RQ6 Q9NQH9 Q9H4H2 Q9BQW2 Q9UJP6 D3DW12 O60325 Q5TFF7 Q9NQ65 D3DW13 Q9NQ66 Q9UM26
|
| Accessions |
CBF62960 CBF74720 CBU87836 CBU96783 EAX10372 EAX10373 EAX10374 EAX10375 EAX10376 Q9NQ66 AB011153 BAA25507 AJ278313 CAB98142 AJ278314 CAB98143 AK023689 BAB14641 AK127693 BAG54550 AK299195 BAG61238 AK310597 AL137267 CAB70666 AY004175 AAF86613 BC069420 AAH69420 BC117231 AAI17232 BQ184058 HQ258537 ADR83291 XM_011529199 XP_011527501 XM_011529200 XP_011527502 XM_011529201 XP_011527503 XM_011529202 XP_011527504 XM_011529203 XP_011527505 NM_015192 NP_056007 NM_182734 NP_877398
|
| Function |
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
|
| Subcellular Location |
Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250}.
|
| Top Pathways |
Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Estrogen signaling pathway, Inflammatory mediator regulation of TRP channels
|
![Western Blot: Phospholipase C beta 1 Overexpression Lysate (Adult Normal) [NBL1-14488] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Phospholipase C beta 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9252_Phospholipase%2520C%2520beta%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14488-img0002.jpg)