PLCB1

Gene Symbol	PLCB1
Entrez Gene	23236
Alt Symbol	EIEE12, PI-PLC, PLC-154, PLC-I, PLC154, PLCB1A, PLCB1B
Species	Human
Gene Type	protein-coding
Description	phospholipase C, beta 1 (phosphoinositide-specific)
Other Description	1-phosphatidyl-D-myo-inositol-4,5-bisphosphate\|1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1\|PLC-beta-1\|inositoltrisphosphohydrolase\|monophosphatidylinositol phosphodiesterase\|phosphoinositidase C\|phospholipase C-I\|triphosphoinositide phosphodiesterase
Swissprots	Q9NTH4 Q9H8H5 Q5TGC9 Q8IV93 Q17RQ6 Q9NQH9 Q9H4H2 Q9BQW2 Q9UJP6 D3DW12 O60325 Q5TFF7 Q9NQ65 D3DW13 Q9NQ66 Q9UM26
Accessions	CBF62960 CBF74720 CBU87836 CBU96783 EAX10372 EAX10373 EAX10374 EAX10375 EAX10376 Q9NQ66 AB011153 BAA25507 AJ278313 CAB98142 AJ278314 CAB98143 AK023689 BAB14641 AK127693 BAG54550 AK299195 BAG61238 AK310597 AL137267 CAB70666 AY004175 AAF86613 BC069420 AAH69420 BC117231 AAI17232 BQ184058 HQ258537 ADR83291 XM_011529199 XP_011527501 XM_011529200 XP_011527502 XM_011529201 XP_011527503 XM_011529202 XP_011527504 XM_011529203 XP_011527505 NM_015192 NP_056007 NM_182734 NP_877398
Function	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Subcellular Location	Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes. {ECO:0000250}.
Top Pathways	Adrenergic signaling in cardiomyocytes, cGMP-PKG signaling pathway, Thyroid hormone synthesis, Estrogen signaling pathway, Inflammatory mediator regulation of TRP channels

PLC β1 (D-8) - sc-5291 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

PLC β1 (D-8): sc-5291. Western blot analysis of PLC β1 expression in U-937 (A) and NIH/3T3 (B) whole cell lysates.

PLC β1 (G-12) - sc-205 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

PLC β1 (G-12): sc-205. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing membrane and cytoplasmic staining.

PLC β1 (R-233) - sc-9050 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

PLC β1 (R-233): sc-9050. Western blot analysis of PLC β1 expression in HeLa whole cell lysate (A) and mouse brain tissue extract (B).

PLC β1 (S-20) - sc-31755 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

PLC β1 (S-20): sc-31755. Western blot analysis of PLC β1 expression in NIH/3T3 whole cell lysate.

PLC β1 (16) - sc-136040 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

PLC β1 (16): sc-136040. Western blot analysis of PLC β1 expression in rat cerebrum tissue extract.

Anti-Phospholipase C beta 1 antibody - ab21824 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-Phospholipase C beta 1 antibody (ab21824) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ugLane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ug SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-Phospholipase C beta 1 antibody - ab103278 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Phospholipase C beta 1 antibody (ab103278) at 1/50 dilution + HL-60 cell lysate at 35 µg

Anti-Phospholipase C beta 1 antibody - ab41863 from Abcam

Prices	$370.00
Sizes	500 µl
Host	Rabbit
Clonality	Polyclonal

Ab41863 staining human Phospholipase C beta 1 in human brain by immunohistochemistry using formalin fixed paraffin embedded tissue.

Anti-Phospholipase C beta 1 antibody, prediluted - ab41864 from Abcam

Prices	$370.00
Sizes	7 ml
Host	Rabbit
Clonality	Polyclonal

Ab41864 staining human Phospholipase C beta 1 in human brain by immunohistochemistry using formalin fixed paraffin embedded tissue.

Anti-PLCB1 / Phospholipase C Beta 1 Antibody - LS-C9587 from LifeSpan Bioscience

Prices	$515.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-PLCB1 / Phospholipase C Beta 1 Antibody - LS-C152760 from LifeSpan Bioscience

Prices	$365.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-PLCB1 / Phospholipase C Beta 1 Antibody (C-Terminus) - LS-C50444 from LifeSpan Bioscience

Prices	$530.00
Sizes	250 µl
Host	Rabbit
Clonality	Polyclonal

Anti-PLCB1 / Phospholipase C Beta 1 Antibody (C-Terminus) - LS-C345891 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Plcb1 Antibody - C-terminal region in Mouse Testis cells lysate.

Anti-PLCB1 / Phospholipase C Beta 1 Antibody (C-Terminus) - LS-C107749 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

PLCB1 antibody LS-C107749 Western blot of HepG2 cell lysate.

Anti-PLCB1 / Phospholipase C Beta 1 Antibody - LS-C193037 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts of HL-60 cell lines, using PLCB1 antibody.

Anti-PLCB1 / Phospholipase C Beta 1 Antibody (aa1148-1176) - LS-C163772 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of PLCB1 Antibody in HL-60 cell line lysates (35 ug/lane). PLCB1 (arrow) was detected using the purified antibody.

Anti-PLCB1 / Phospholipase C Beta 1 Antibody - LS-C331795 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of paraffin-embedded rat lung using PLCB1 antibody at dilution of 1:200 (400x lens).

PLC-beta 1 Antibody - AF4466 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Sheep
Clonality	Polyclonal

PLC-beta 1 Antibody - NBP1-58257 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: PLC-beta 1 Antibody [NBP1-58257] - HepG2 cell lysate, concentration 0.2-1 ug/ml.

PLC-beta 1 Antibody - NBP2-38220 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

PLC-beta 1 Antibody - NBP1-36354 from Novus Biologicals

Prices	$279.00, $329.00, $499.00
Sizes	100 µl, 500 µl, 1 ml
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: PLC-beta 1 Antibody [NBP1-36354] - Human Brain.

PLC-beta 1 Antibody - NBP2-37966 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: PLC-beta 1 Antibody [NBP2-37966] - Staining of human lateral ventricle shows moderate cytoplasmic and nucleolar positivity in neuronal cells.

PLC-beta 1 Antibody - H00023236-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Phospholipase C beta 1 Antibody - bs-6976R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit

Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti PLC β1/Phospholipase C beta 1 Polyclonal Antibody, Unconjugated (bs-6976R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-PLCB1 (21-35) antibody produced in rabbit - SAB1101340 from Sigma-Aldrich

Prices	$328.50
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunofluorescence</B><BR/>Anti- PLCB1 (21-35) (RB): <B>Cat. No. SAB1101340</B>: Immunofluorescence of HUVEC cells using Anti-PLCB1 (21-35) (RB) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Search more