AXIN1

Gene Symbol	AXIN1
Entrez Gene	8312
Alt Symbol	AXIN, PPP1R49
Species	Human
Gene Type	protein-coding
Description	axin 1
Other Description	axin-1|axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of|protein phosphatase 1, regulatory subunit 49
Swissprots	Q4TT26 Q8WVW6 O15169 Q96S28 Q86YA7 Q4TT27
Accessions	AAK61224 CAI95589 CAI95590 CAQ09649 EAW85835 EAW85836 O15169 AB208876 BAD92113 AF009674 AAC51624 BC017447 AAH17447 BC035872 BC044648 AAH44648 BX648449 DB460285 KF615847 KF615848 KF615849 KF615850 KF615851 KF615852 KF615853 KF615854 XM_011522682 XP_011520984 XM_011522683 XP_011520985 XM_011522684 XP_011520986 XM_011522685 XP_011520987 XM_011522686 XP_011520988 XM_011522687 XP_011520989 XM_011522688 XP_011520990 NM_003502 NP_003493 NM_181050 NP_851393
Function	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684}.
Subcellular Location	Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

AXIN1 overexpression lysate - LY405798 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

AXIN1 overexpression lysate - LY418638 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

Axin-1 Overexpression Lysate (Native) - NBP2-04933 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Axin-1 Overexpression Lysate (Native) - NBP2-10887 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human AXIN1 Knockdown Stable Cell Line - CSC-DC001247 from Creative biogene Category Cell Line Species Human

Human AXIN1 Knockout Cell Line-HeLa - CSC-RT1339 from Creative biogene Category Cell Line Species Human

AXIN1 KO Cell Lysate-HeLa - CLKO-1191 from Creative biogene Category Cell Lysate

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