AXIN1
| Gene Symbol | AXIN1 |
|---|---|
| Entrez Gene | 8312 |
| Alt Symbol | AXIN, PPP1R49 |
| Species | Human |
| Gene Type | protein-coding |
| Description | axin 1 |
| Other Description | axin-1|axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of|protein phosphatase 1, regulatory subunit 49 |
| Swissprots | Q4TT26 Q8WVW6 O15169 Q96S28 Q86YA7 Q4TT27 |
| Accessions | AAK61224 CAI95589 CAI95590 CAQ09649 EAW85835 EAW85836 O15169 AB208876 BAD92113 AF009674 AAC51624 BC017447 AAH17447 BC035872 BC044648 AAH44648 BX648449 DB460285 KF615847 KF615848 KF615849 KF615850 KF615851 KF615852 KF615853 KF615854 XM_011522682 XP_011520984 XM_011522683 XP_011520985 XM_011522684 XP_011520986 XM_011522685 XP_011520987 XM_011522686 XP_011520988 XM_011522687 XP_011520989 XM_011522688 XP_011520990 NM_003502 NP_003493 NM_181050 NP_851393 |
| Function | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684}. |
| Subcellular Location | Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX. {ECO:0000250}. |
| Tissue Specificity | Ubiquitously expressed. |
| Top Pathways | Wnt signaling pathway, Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Hippo signaling pathway |
Axin CRISPR/Cas9 KO Plasmid (h) - sc-401074 from Santa Cruz Biotechnology
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Axin HDR Plasmid (h) - sc-401074-HDR from Santa Cruz Biotechnology
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Axin Double Nickase Plasmid (h) - sc-401074-NIC from Santa Cruz Biotechnology
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Axin Double Nickase Plasmid (h2) - sc-401074-NIC-2 from Santa Cruz Biotechnology
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Axin CRISPR Activation Plasmid (h) - sc-401074-ACT from Santa Cruz Biotechnology
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Axin CRISPR Activation Plasmid (h2) - sc-401074-ACT-2 from Santa Cruz Biotechnology
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Axin Lentiviral Activation Particles (h) - sc-401074-LAC from Santa Cruz Biotechnology
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Axin Lentiviral Activation Particles (h2) - sc-401074-LAC-2 from Santa Cruz Biotechnology
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Axin siRNA (h) - sc-41449 from Santa Cruz Biotechnology
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Axin shRNA Plasmid (h) - sc-41449-SH from Santa Cruz Biotechnology
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Axin shRNA (h) Lentiviral Particles - sc-41449-V from Santa Cruz Biotechnology
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Axin-1 RNAi - H00008312-R02 from Novus Biologicals
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Axin-1 RNAi - H00008312-R01 from Novus Biologicals
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MISSION® esiRNA - EHU073901 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3785 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3785 from Sigma-Aldrich
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AXIN1 siRNA (Human) - CRH5436 from Cohesion Biosciences
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AXIN1 - MBS8218286 from MyBioSource
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shRNA set against Human AXIN1 (NM_003502.3) - SHH243938 from Creative biogene
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AXIN1 shRNA Plasmid (Human) - CHH5436 from Cohesion Biosciences
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AXIN1 miRNA 3'UTR clone - MiUTR3H-06288 from Creative biogene
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AXIN1 miRNA 3'UTR clone - MiUTR3H-06289 from Creative biogene
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