AXIN1

Gene Symbol AXIN1
Entrez Gene 8312
Alt Symbol AXIN, PPP1R49
Species Human
Gene Type protein-coding
Description axin 1
Other Description axin-1|axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of|protein phosphatase 1, regulatory subunit 49
Swissprots Q4TT26 Q8WVW6 O15169 Q96S28 Q86YA7 Q4TT27
Accessions AAK61224 CAI95589 CAI95590 CAQ09649 EAW85835 EAW85836 O15169 AB208876 BAD92113 AF009674 AAC51624 BC017447 AAH17447 BC035872 BC044648 AAH44648 BX648449 DB460285 KF615847 KF615848 KF615849 KF615850 KF615851 KF615852 KF615853 KF615854 XM_011522682 XP_011520984 XM_011522683 XP_011520985 XM_011522684 XP_011520986 XM_011522685 XP_011520987 XM_011522686 XP_011520988 XM_011522687 XP_011520989 XM_011522688 XP_011520990 NM_003502 NP_003493 NM_181050 NP_851393
Function Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684}.
Subcellular Location Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX. {ECO:0000250}.
Tissue Specificity Ubiquitously expressed.
Top Pathways Wnt signaling pathway, Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Hippo signaling pathway

Axin1 (C76H11) Rabbit mAb - 2087 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C76H11
Western blot analysis of extracts from various cell lines using Axin1 (C76H11) Rabbit mAb.

Axin1 (C7B12) Rabbit mAb - 3323 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C7B12
Western blot analysis of total extracts from various cell lines using Axin1 (C7B12) Rabbit mAb.

Axin1 (C95H11) Rabbit mAb - 2074 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C95H11
Western blot analysis of extracts from various cell lines using Axin1 (C95H11) Rabbit mAb.

Axin (H-98) - sc-14029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Axin (H-98): sc-14029. Western blot analysis of Axin expression of K-562 (A), HeLa (B) and SK-N-SH (C) whole cell lysates and HeLa nuclear extract (D).

Axin (R-20) - sc-8568 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Axin (S-20) - sc-8567 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Axin (S-20): sc-8567. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lymph node tissue showing cytoplasmic and nuclear staining of cells in germinal and non-germinal centers.

Anti-Axin 1 antibody - ab133221 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin fixed, paraffin embedded Human skin labelling Axin 1 with ab133221 at 5 ug/ml, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Axin 1 antibody - ab130652 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Axin 1 antibody (ab130652) at 1/100 dilution + MDA-MB453 cell line lysate at 35 µg

Anti-Axin 1 antibody - ab96856 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Axin 1 antibody (ab96856) at 1/1500 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Axin 1 antibody - ab56475 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56475 Axin 1 antibody at 1ug/ml.

Anti-Axin 1 antibody - ab4157 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
All lanes : Anti-Axin 1 antibody (ab4157) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab27252)Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lysates/proteins at 20 µg per lane.SecondaryGoat IgG secondary antibody (ab28445) at 1/10000 dilution

Anti-Axin 1 antibody - ab93119 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa898-912) - LS-C20823 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (Internal) - LS-C20825 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody - LS-C113064 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-AXIN1 / Axin-1 Antibody (N-Terminus) - LS-C126940 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-AXIN1 / Axin-1 Antibody (aa717-746, AP) - LS-C252157 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa717-746, APC) - LS-C252158 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa717-746, Biotin) - LS-C252159 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa898-912) - LS-C152734 from LifeSpan Bioscience

Prices $425.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal
WB: Lysates of Cos-1 cells untransfected (lane 1) and expressing transfected Axin (lane 2) were probed with anti-Axin (1g/ml).

Anti-AXIN1 / Axin-1 Antibody (aa717-746, FITC) - LS-C252160 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa800-862) - LS-C185643 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: A431, B: H1299. 7.5% SDS PAGE. AXIN antibody diluted at 1:1500

Anti-AXIN1 / Axin-1 Antibody (aa8-62) - LS-C170194 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa717-746, Azide-free, HRP) - LS-C252161 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-AXIN1 / Axin-1 Antibody (aa329-359, AP) - LS-C252163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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