AXIN1

Gene Symbol	AXIN1
Entrez Gene	8312
Alt Symbol	AXIN, PPP1R49
Species	Human
Gene Type	protein-coding
Description	axin 1
Other Description	axin-1|axis inhibition protein 1|axis inhibitor 1|fused, mouse, homolog of|protein phosphatase 1, regulatory subunit 49
Swissprots	Q4TT26 Q8WVW6 O15169 Q96S28 Q86YA7 Q4TT27
Accessions	AAK61224 CAI95589 CAI95590 CAQ09649 EAW85835 EAW85836 O15169 AB208876 BAD92113 AF009674 AAC51624 BC017447 AAH17447 BC035872 BC044648 AAH44648 BX648449 DB460285 KF615847 KF615848 KF615849 KF615850 KF615851 KF615852 KF615853 KF615854 XM_011522682 XP_011520984 XM_011522683 XP_011520985 XM_011522684 XP_011520986 XM_011522685 XP_011520987 XM_011522686 XP_011520988 XM_011522687 XP_011520989 XM_011522688 XP_011520990 NM_003502 NP_003493 NM_181050 NP_851393
Function	Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt- independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684}.
Subcellular Location	Cytoplasm. Nucleus. Membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Note=MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX. {ECO:0000250}.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Axin 1 peptide - ab23000 from Abcam Category Peptide Prices $176.00 Sizes 100 µg Species Human

AXIN1 / Axin-1 Antibody Blocking Peptide - LS-E1378 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AXIN1 / Axin-1 Antibody Blocking Peptide - LS-E4821 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AXIN1 / Axin-1 Antibody Blocking Peptide - LS-E25329 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AXIN1 / Axin-1 Antibody Blocking Peptide - LS-E31014 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

AXIN1 / Axin-1 Antibody Blocking Peptide - LS-E15777 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Axin-1 Protein - H00008312-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Axin-1 Blocking Peptide - NBP1-76483PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

AXIN1-Antibody-C-term-Blocking-peptide - BP12033b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AXIN1-Antibody-Center-Blocking-Peptide - BP17201c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

AXIN1 blocking peptide - GTX89836-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

Axin-1 Blocking Peptide - abx064219 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Human AXIN Protein - abx065488 from Abbexa Category Protein Source E.coli Species Human

Axin 1 Peptide - AC21-0157-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Axin-1 - H00008312-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Axin-1 - H00008312-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Axin-1 control peptide - AP26283CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

AXIN1 Peptide - 45-310P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

AXIN1 Peptide - 6005P from ProSci Category Peptide Species Human

AXIN1 fusion protein - Ag10079 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

AXIN1 fusion protein - Ag9858 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human AXIN - AXIN-3795H from Creative Biomart Category Protein Source E. Coli Species Human

Recombinant Human AXIN1, His-tagged - AXIN1-26564TH from Creative Biomart Category Protein Source E. coli

Recombinant Human AXIN1, His-tagged - AXIN1-10084H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human AXIN1 - AXIN1-665H from Creative Biomart Category Protein Source Mammalian Cells Species Human

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