| Gene Symbol |
MPHOSPH8
|
| Entrez Gene |
54737
|
| Alt Symbol |
HSMPP8, TWA3, mpp8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
M-phase phosphoprotein 8
|
| Other Description |
M-phase phosphoprotein, mpp|M-phase phosphoprotein, mpp8|two hybrid-associated protein 3 with RanBPM
|
| Swissprots |
B7Z6F9 Q5JPE5 Q86TK3 Q5JTQ0 Q99549 Q96MK4 Q9BTP1
|
| Accessions |
EAX08228 EAX08229 EAX08230 Q99549 AJ293409 AK056785 BAB71284 AK092556 BAG52572 AK300258 BAH13245 AL832864 CAI46172 BC003542 AAH03542 BC017322 BC046214 AAH46214 DA672302 R60056 X98259 CAA66912 XM_005266436 XP_005266493 XM_011535124 XP_011533426 XR_941609 NM_017520 NP_059990
|
| Function |
Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. {ECO:0000269|PubMed:20871592}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:8885239}. Note=Detected on heterochromatin. Detected on nucleosomes.
|