Gene Symbol | MPHOSPH8 |
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Entrez Gene | 54737 |
Alt Symbol | HSMPP8, TWA3, mpp8 |
Species | Human |
Gene Type | protein-coding |
Description | M-phase phosphoprotein 8 |
Other Description | M-phase phosphoprotein, mpp|M-phase phosphoprotein, mpp8|two hybrid-associated protein 3 with RanBPM |
Swissprots | B7Z6F9 Q5JPE5 Q86TK3 Q5JTQ0 Q99549 Q96MK4 Q9BTP1 |
Accessions | EAX08228 EAX08229 EAX08230 Q99549 AJ293409 AK056785 BAB71284 AK092556 BAG52572 AK300258 BAH13245 AL832864 CAI46172 BC003542 AAH03542 BC017322 BC046214 AAH46214 DA672302 R60056 X98259 CAA66912 XM_005266436 XP_005266493 XM_011535124 XP_011533426 XR_941609 NM_017520 NP_059990 |
Function | Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. {ECO:0000269|PubMed:20871592}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:8885239}. Note=Detected on heterochromatin. Detected on nucleosomes. |
Human MPP8 full length protein - ab162825 from Abcam
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Human MPP8 protein fragment - ab162826 from Abcam
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Recombinant Human mpp8 Protein - H00054737-Q01 from Novus Biologicals
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Recombinant Human mpp8 Protein - H00054737-P01 from Novus Biologicals
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MPHOSPH8 - H00054737-P01-10 from Acris Antibodies
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MPHOSPH8 - H00054737-P01-25 from Acris Antibodies
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MPHOSPH8 - H00054737-Q01-10 from Acris Antibodies
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MPHOSPH8 - H00054737-Q01-25 from Acris Antibodies
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MPHOSPH8 fusion protein - Ag10258 from Proteintech Group
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MPHOSPH8 fusion protein - Ag10268 from Proteintech Group
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Recombinant Human M-phase phosphoprotein 8(MPHOSPH8) ,partial - CSB-YP014752HU CSB-EP014752HU CSB-BP014752HU CSB-MP014752HU from Cusabio
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mpp8 Protein - NBP1-92136PEP from Novus Biologicals
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mpp8 Recombinant Protein Antigen - NBP1-92135PEP from Novus Biologicals
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MPP8-Antibody-N-term-Blocking-peptide - BP5718a from Abgent, a WuXi AppTec company
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MPHOSPH8 Peptide, Human - M34GP09672H from Creative Peptides
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M-phase phosphoprotein 8 (MPHOSPH8), partial, Recombinant Protein - MBS1449602 from MyBioSource
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