Gene Symbol | MPHOSPH8 |
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Entrez Gene | 54737 |
Alt Symbol | HSMPP8, TWA3, mpp8 |
Species | Human |
Gene Type | protein-coding |
Description | M-phase phosphoprotein 8 |
Other Description | M-phase phosphoprotein, mpp|M-phase phosphoprotein, mpp8|two hybrid-associated protein 3 with RanBPM |
Swissprots | B7Z6F9 Q5JPE5 Q86TK3 Q5JTQ0 Q99549 Q96MK4 Q9BTP1 |
Accessions | EAX08228 EAX08229 EAX08230 Q99549 AJ293409 AK056785 BAB71284 AK092556 BAG52572 AK300258 BAH13245 AL832864 CAI46172 BC003542 AAH03542 BC017322 BC046214 AAH46214 DA672302 R60056 X98259 CAA66912 XM_005266436 XP_005266493 XM_011535124 XP_011533426 XR_941609 NM_017520 NP_059990 |
Function | Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression. {ECO:0000269|PubMed:20871592}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20871592, ECO:0000269|PubMed:8885239}. Note=Detected on heterochromatin. Detected on nucleosomes. |
MPHOSPH8 CRISPR/Cas9 KO Plasmid (h) - sc-407963 from Santa Cruz Biotechnology
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MPHOSPH8 HDR Plasmid (h) - sc-407963-HDR from Santa Cruz Biotechnology
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MPHOSPH8 Double Nickase Plasmid (h) - sc-407963-NIC from Santa Cruz Biotechnology
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MPHOSPH8 Double Nickase Plasmid (h2) - sc-407963-NIC-2 from Santa Cruz Biotechnology
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MPHOSPH8 CRISPR Activation Plasmid (h) - sc-407963-ACT from Santa Cruz Biotechnology
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MPHOSPH8 CRISPR Activation Plasmid (h2) - sc-407963-ACT-2 from Santa Cruz Biotechnology
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MPHOSPH8 Lentiviral Activation Particles (h) - sc-407963-LAC from Santa Cruz Biotechnology
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MPHOSPH8 Lentiviral Activation Particles (h2) - sc-407963-LAC-2 from Santa Cruz Biotechnology
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MPHOSPH8 siRNA (h) - sc-106234 from Santa Cruz Biotechnology
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MPHOSPH8 shRNA Plasmid (h) - sc-106234-SH from Santa Cruz Biotechnology
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MPHOSPH8 shRNA (h) Lentiviral Particles - sc-106234-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU070171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14497 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14497 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05547 from Sigma-Aldrich
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MPHOSPH8 siRNA (Human) - CRJ0189 from Cohesion Biosciences
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shRNA set against Human MPHOSPH8 (NM_017520.3) - SHH343848 from Creative biogene
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Human MPHOSPH8 siRNA - orb270690 from Biorbyt
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MPHOSPH8 shRNA Plasmid (Human) - CHJ0189 from Cohesion Biosciences
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MPHOSPH8 miRNA 3'UTR clone - MiUTR3H-12021 from Creative biogene
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