| Gene Symbol |
PCBP2
|
| Entrez Gene |
5094
|
| Alt Symbol |
HNRNPE2, HNRPE2, hnRNP-E2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly(rC) binding protein 2
|
| Other Description |
alpha-CP2|heterogeneous nuclear ribonucleoprotein E2|heterogenous nuclear ribonucleoprotein E2|hnRNP E2|poly(rC)-binding protein 2
|
| Swissprots |
I6L8F9 Q6PKG5 Q59HD4 Q15366 Q32Q82 B4DXP5 Q6IPF4 Q68Y55 F8VYL7 G3V0E8 A8K7X6
|
| Accessions |
CAD88579 CAD88580 CAJ42709 EAW96706 EAW96707 EAW96708 EAW96709 EAW96710 EAW96711 Q15366 AB188306 BAD36897 AB208825 BAD92062 AK023529 AK123458 AK130583 AK225357 AK292141 BAF84830 AK299210 BAG61249 AK302067 BAG63457 BC001155 AAH01155 BC035420 BC071942 AAH71942 BC107688 AAI07689 BE748080 BF509278 BM764315 BU844465 CX164318 X78136 CAA55015 NM_001098620 NP_001092090 NM_001128911 NP_001122383 NM_001128912 NP_001122384 NM_001128913 NP_001122385 NM_001128914 NP_001122386 NM_005016 NP_005007 NM_031989 NP_114366
|
| Function |
Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation. {ECO:0000269|PubMed:19881509}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19029303}. Cytoplasm {ECO:0000269|PubMed:19029303}. Note=Loosely bound in the nucleus. May shuttle between the nucleus and the cytoplasm.
|
| Tissue Specificity |
Detected in all tissues examined.
|