MFN2

Gene Symbol	MFN2
Entrez Gene	9927
Alt Symbol	CMT2A, CMT2A2, CPRP1, HSG, MARF
Species	Human
Gene Type	protein-coding
Description	mitofusin 2
Other Description	hyperplasia suppressor|mitochondrial assembly regulatory factor|mitofusin-2|transmembrane GTPase MFN2
Swissprots	Q5JXC4 A8K1B3 Q9NSX8 O95140 Q9H131 Q5JXC3 O95572
Accessions	EAW71726 EAW71727 O95140 AF036536 AAD02058 AI857365 AK001189 BAG50864 AK021947 BAG51062 AK022453 BAG51075 AK289828 BAF82517 AK295890 BAH12214 AL122114 AL137666 CAB70866 AY028429 AAK18728 BC017061 AAH17061 BU178912 D86987 BAA34389 DC401346 DQ894181 ABM85107 EU176270 ABW03721 XM_005263543 XP_005263600 XM_005263545 XP_005263602 XM_005263547 XP_005263604 XM_005263548 XP_005263605 NM_001127660 NP_001121132 NM_014874 NP_055689
Function	Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, EC
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}; Multi- pass membrane protein {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}. Note=Colocalizes with BAX during apoptosis.
Tissue Specificity	Ubiquitous; expressed at low level. Highly expressed in heart and kidney. {ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

mitofusin 2, ELISA Kit - MBS9339897 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

Mitofusin 2 (MFN2), ELISA Kit - MBS2024886 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.055ng/mL. Range 0.156-10ng/mL.

ELISA Kit for Mitofusin 2 (MFN2) - SEF591Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.055ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Mitofusin 2 ELISA Kit - abx156904 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Human Mitofusin 2 / MFN2 ELISA Kit (Sandwich ELISA) - LS-F25496 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.055 ng/ml Range 0.156-10 ng/ml

Human Mitofusin 2 (MFN2) ELISA Kit - EKU09220 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.055 ng/mL Range 0.156-10 ng/mL

Human MFN2 ELISA Kit - E024694 from Biobool Category ELISA Kit Sensitivity Typically less than 0.055ng/mL.

MFN2 ELISA Kit (Human) (OKCD00471) - OKCD00471 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.055 ng/mL Range 0.156-10 ng/mL

anti-Mitofusin 2 antibody - ARG55276 from Arigo Biolaboratories Category ELISA Kit

Mitofusin-2 (MFN2), ELISA Kit - MBS9392641 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392648 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392634 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392637 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392635 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392636 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392640 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392645 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392638 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392642 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392644 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392643 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392639 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitofusin-2 (MFN2), ELISA Kit - MBS9392646 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

MFN2 (Mitofusin-2), ELISA Kit - MBS7606550 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/ml Range 31.25-2000pg/ml

Mitofusin-2 (MFN2), ELISA Kit - MBS9392647 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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