MFN2

Gene Symbol	MFN2
Entrez Gene	9927
Alt Symbol	CMT2A, CMT2A2, CPRP1, HSG, MARF
Species	Human
Gene Type	protein-coding
Description	mitofusin 2
Other Description	hyperplasia suppressor|mitochondrial assembly regulatory factor|mitofusin-2|transmembrane GTPase MFN2
Swissprots	Q5JXC4 A8K1B3 Q9NSX8 O95140 Q9H131 Q5JXC3 O95572
Accessions	EAW71726 EAW71727 O95140 AF036536 AAD02058 AI857365 AK001189 BAG50864 AK021947 BAG51062 AK022453 BAG51075 AK289828 BAF82517 AK295890 BAH12214 AL122114 AL137666 CAB70866 AY028429 AAK18728 BC017061 AAH17061 BU178912 D86987 BAA34389 DC401346 DQ894181 ABM85107 EU176270 ABW03721 XM_005263543 XP_005263600 XM_005263545 XP_005263602 XM_005263547 XP_005263604 XM_005263548 XP_005263605 NM_001127660 NP_001121132 NM_014874 NP_055689
Function	Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, EC
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}; Multi- pass membrane protein {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}. Note=Colocalizes with BAX during apoptosis.
Tissue Specificity	Ubiquitous; expressed at low level. Highly expressed in heart and kidney. {ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Mitofusin 2 protein fragment - ab153026 from Abcam Category Protein Source Wheat germ Species Human

Mitofusin 2 / MFN2 Antibody Blocking Peptide - LS-E9809 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Mitofusin 2 / MFN2 Antibody Blocking Peptide - LS-E15618 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Mitofusin 2 Protein - H00009927-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MFN2-Antibody-Center-Blocking-Peptide - BP8840c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Mitofusin 2 Blocking Peptide - 33R-8895 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Mitofusin 2 Blocking Peptide - 33R-4923 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Mitofusin 2 Blocking Peptide - 33R-10971 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Mitofusin-2 - H00009927-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Mitofusin-2 - H00009927-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MFN2 Peptide - 7863P from ProSci Category Peptide Species Human

MFN2 fusion protein - ag2845 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human MFN2, MYC/DDK-tagged - MFN2-36H from Creative Biomart Category Protein Source HEK293 cells Species Human

Mfn2 (F403) Peptide - BS3682P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Mitofusin 2 Blocking Peptide - 3882BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

MFN2 Blocking Peptide - abx161675 from Abbexa Category Peptide Species Human, Monkey

Mitofusin-2 (transcript variant 2) - TP326143 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Mitofusin-2 (transcript variant 1) - TP302218 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Mitofusin 2, Peptide - MBS843823 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Mitofusin 2 Recombinant Protein Antigen - NBP1-85477PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MFN2 Peptide, Human - M34GP09462H from Creative Peptides Category Peptide Source Synthetic. Species Human

MFN2 Blocking Peptide - CBP4464 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

Recombinant Human Mitofusin-2(MFN2), partial - CSB-YP013756HU1 from Cusabio Category Protein Source Yeast Species Human

MFN2 Blocking Peptide - orb392809 from Biorbyt Category Peptide Prices $238.00, $476.00 Sizes 1 mg, 5 mg Species Human, Mouse

Mitofusin-2 (MFN2), Recombinant Protein - MBS1087851 from MyBioSource Category Protein Prices $1,035.00, $1,035.00, $1,265.00, $1,265.00, $1,550.00, $1,550.00, $2,010.00, $2,010.00, $2,045.00, $3,060.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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