MFN2

Gene Symbol	MFN2
Entrez Gene	9927
Alt Symbol	CMT2A, CMT2A2, CPRP1, HSG, MARF
Species	Human
Gene Type	protein-coding
Description	mitofusin 2
Other Description	hyperplasia suppressor|mitochondrial assembly regulatory factor|mitofusin-2|transmembrane GTPase MFN2
Swissprots	Q5JXC4 A8K1B3 Q9NSX8 O95140 Q9H131 Q5JXC3 O95572
Accessions	EAW71726 EAW71727 O95140 AF036536 AAD02058 AI857365 AK001189 BAG50864 AK021947 BAG51062 AK022453 BAG51075 AK289828 BAF82517 AK295890 BAH12214 AL122114 AL137666 CAB70866 AY028429 AAK18728 BC017061 AAH17061 BU178912 D86987 BAA34389 DC401346 DQ894181 ABM85107 EU176270 ABW03721 XM_005263543 XP_005263600 XM_005263545 XP_005263602 XM_005263547 XP_005263604 XM_005263548 XP_005263605 NM_001127660 NP_001121132 NM_014874 NP_055689
Function	Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, EC
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}; Multi- pass membrane protein {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}. Note=Colocalizes with BAX during apoptosis.
Tissue Specificity	Ubiquitous; expressed at low level. Highly expressed in heart and kidney. {ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mfn2 CRISPR/Cas9 KO Plasmid (h) - sc-400536 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 HDR Plasmid (h) - sc-400536-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 Double Nickase Plasmid (h) - sc-400536-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 Double Nickase Plasmid (h2) - sc-400536-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 CRISPR Activation Plasmid (h) - sc-400536-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 CRISPR Activation Plasmid (h2) - sc-400536-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 Lentiviral Activation Particles (h) - sc-400536-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 Lentiviral Activation Particles (h2) - sc-400536-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Mfn2 siRNA (h) - sc-43928 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mfn2 shRNA Plasmid (h) - sc-43928-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mfn2 shRNA (h) Lentiviral Particles - sc-43928-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Mitofusin 2 RNAi - H00009927-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Mitofusin 2 RNAi - H00009927-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU044111 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13255 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13255 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10699 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10699

MFN2 siRNA (Human) - CRH6672 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human MFN2 (NM_014874.3) - SHH341115 from Creative biogene Category siRNA Species Reactivities Human

Human MFN2 siRNA - orb267174 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MFN2 shRNA Plasmid (Human) - CHH6672 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MFN2 miRNA 3'UTR clone - MiUTR3H-10051 from Creative biogene Species Reactivities Human

MFN2 miRNA 3'UTR clone - MiUTR3H-10052 from Creative biogene Species Reactivities Human

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