MFN2

Gene Symbol MFN2
Entrez Gene 9927
Alt Symbol CMT2A, CMT2A2, CPRP1, HSG, MARF
Species Human
Gene Type protein-coding
Description mitofusin 2
Other Description hyperplasia suppressor|mitochondrial assembly regulatory factor|mitofusin-2|transmembrane GTPase MFN2
Swissprots Q5JXC4 A8K1B3 Q9NSX8 O95140 Q9H131 Q5JXC3 O95572
Accessions EAW71726 EAW71727 O95140 AF036536 AAD02058 AI857365 AK001189 BAG50864 AK021947 BAG51062 AK022453 BAG51075 AK289828 BAF82517 AK295890 BAH12214 AL122114 AL137666 CAB70866 AY028429 AAK18728 BC017061 AAH17061 BU178912 D86987 BAA34389 DC401346 DQ894181 ABM85107 EU176270 ABW03721 XM_005263543 XP_005263600 XM_005263545 XP_005263602 XM_005263547 XP_005263604 XM_005263548 XP_005263605 NM_001127660 NP_001121132 NM_014874 NP_055689
Function Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions. {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, EC
Subcellular Location Mitochondrion outer membrane {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}; Multi- pass membrane protein {ECO:0000269|PubMed:11181170, ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12499352, ECO:0000269|PubMed:23620051}. Note=Colocalizes with BAX during apoptosis.
Tissue Specificity Ubiquitous; expressed at low level. Highly expressed in heart and kidney. {ECO:0000269|PubMed:11950885, ECO:0000269|PubMed:12759376}.

Mitofusin-2 (D1E9) Rabbit mAb - 11925 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1E9
Western blot analysis of extracts from various cell lines using Mitofusin-2 (D1E9) Rabbit mAb.

Mitofusin-2 (D2D10) Rabbit mAb - 9482 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2D10
Western blot analysis of extracts from various cell lines using Mitofusin-2 (D2D10) Rabbit mAb.

Mfn2 (C-16) - sc-30367 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Mfn2 (H-68) - sc-50331 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mfn2 (H-68): sc-50331. Western blot analysis of Mfn2 expression in A10 (A) and Hep G2 (B) whole cell lysates.

Mfn2 (Y-19) - sc-30366 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mfn2 (Y-19): sc-30366. Western blot analysis of Mfn2 expression in C6 whole cell lysate.

Mfn2 (XX-1) - sc-100560 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Mfn2 (XX-1): sc-100560. Western blot analysis of Mfn2 expression in HeLa whole cell lysate.

Anti-Mitofusin 2 antibody - ab56889 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ab56889 staining mitofusin 2 in MEF1 cells treated with nigericin Na+ salt (ab120494), by ICC/IF. Decrease in mitofusin 2 expression correlates with increased concentration of nigericin Na+ salt, as described in literature.The cells were incubated at 37°C for 3h in media containing different concentrations of ab120494 (nigericin Na+ salt) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab56889 (10 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-mouse polyclonal antibody (ab96879) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

Anti-Mitofusin 2 antibody - ab50838 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Mitofusin 2 antibody (ab50838) at 0.5 µg/mlLanes 2 - 3 : Anti-Mitofusin 2 antibody (ab50838) at 1 µg/mlLane 4 : Anti-Mitofusin 2 antibody (ab50838) at 2 µg/mlLane 1 : rat brain mitochondria extractLane 2 : rat brain mitochondria extractLane 3 : rat brain mitochondria extract with Mitofusin 2 immunizing peptide at 5 µg/mlLane 4 : rat brain mitochondria extractSecondaryGoat Anti-Rabbit IgG, Peroxidase conjugate and a chemiluminescent substratedeveloped using the ECL technique

Anti-Mitofusin 2 antibody - ab50843 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mitofusin 2 antibody (ab50843) at 0.25 µg/mlLane 1 : Rat brain mitochondriaLane 2 : Mouse brain mitochondriaSecondaryGoat Anti-Rabbit IgG, Peroxidase conjugate and a chemiluminescent substrate.

Anti-Mitofusin 2 antibody - ab101055 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Mitofusin 2 antibody - ab191614 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Mitofusin 2 antibody (ab191614) at 1 µg/ml + Human brain tissue lysate at 15 µg

Anti-Mitofusin 2 antibody - ab104632 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Mitofusin 2 antibody - ab88716 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Mitofusin 2 antibody (ab88716) at 4 µg/ml + Jurkat cell lysate

Anti-Mitofusin 2 antibody [NIAR164] - ab124773 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone NIAR164
Anti-Mitofusin 2 antibody [NIAR164] (ab124773) at 1/1000 dilution + Rat primary neurons cell lysate at 20 µgSecondaryAnti-rabbit IgG HRP conjugate at 1/2000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Mitofusin 2 antibody [NIAR164] (HRP) - ab195543 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone NIAR164
Anti-Mitofusin 2 antibody [NIAR164] (HRP) (ab195543) at 1/1000 dilution + Brain (Rat) Tissue Lysate at 10 µgdeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Mitofusin 2 antibody [S153-5] - ab186317 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5

Anti-Mitofusin 2 antibody [S153-5] (HRP) - ab186283 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5

Anti-Mitofusin 2 antibody [S1535] (FITC) - ab186319 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S1535

Anti-Mitofusin 2 antibody - N-terminal - ab189862 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Mitofusin 2 antibody - N-terminal (ab189862) at 1/500 dilutionLane 1 : SW480 cell extractLane 2 : HL60 cell extractLane 3 : HepG2 cell extractLane 4 : 293T cell extractLane 5 : Mouse heart tissue extractLane 6 : Mouse brain tissue extractLane 7 : Mouse kidney tissue extract

Anti-Mitofusin 2 / MFN2 Antibody (Internal) - LS-C336179 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of MFN2 in rat brain tissue with MFN2 antibody at 5 ug/mL.

Anti-Mitofusin 2 / MFN2 Antibody (aa370-600, clone S153-5, PerCP) - LS-C229268 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5

Anti-Mitofusin 2 / MFN2 Antibody (aa370-600, clone S153-5, Atto 390) - LS-C230122 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5

Anti-Mitofusin 2 / MFN2 Antibody (aa370-600, clone S153-5, Atto 594) - LS-C230125 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5

Anti-Mitofusin 2 / MFN2 Antibody (aa370-600, clone S153-5, Atto 488) - LS-C230123 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5

Anti-Mitofusin 2 / MFN2 Antibody (aa370-600, clone S153-5, RPE) - LS-C229269 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S153-5
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