| Gene Symbol |
PTN
|
| Entrez Gene |
5764
|
| Alt Symbol |
HARP, HBGF8, HBNF, NEGF1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleiotrophin
|
| Other Description |
HB-GAM|HBBM|HBGF-8|HBNF-1|OSF-1|heparin affin regulatory protein|heparin binding growth factor 8|heparin-binding brain mitogen|heparin-binding growth factor 8|heparin-binding growth-associated molecule|heparin-binding neurite outgrowth-promoting factor 1|neurite growth-promoting factor 1|osteoblast-specific factor 1|pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
|
| Swissprots |
Q9UCC6 Q5U0B0 Q6ICQ5 P21246
|
| Accessions |
AAB24425 AAB26456 EAL24052 EAW83869 EAW83870 EAW83871 EAW83872 P21246 AK290488 BAF83177 AK313424 BAG36216 AM392897 CAL37775 BC005916 AAH05916 BM968820 BT019692 AAV38498 CR450338 CAG29334 D90226 BAA14261 M57399 AAA35961 X52946 CAA37121 XM_005250515 XP_005250572 XM_005250516 XP_005250573 NM_002825 NP_002816
|
| Function |
Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Osteoblast and brain.
|
![Western Blot: Pleiotrophin Overexpression Lysate (Adult Normal) [NBL1-14957] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Pleiotrophin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12052_Pleiotrophin%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14957-img0002.jpg)