Gene Symbol | PTN |
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Entrez Gene | 5764 |
Alt Symbol | HARP, HBGF8, HBNF, NEGF1 |
Species | Human |
Gene Type | protein-coding |
Description | pleiotrophin |
Other Description | HB-GAM|HBBM|HBGF-8|HBNF-1|OSF-1|heparin affin regulatory protein|heparin binding growth factor 8|heparin-binding brain mitogen|heparin-binding growth factor 8|heparin-binding growth-associated molecule|heparin-binding neurite outgrowth-promoting factor 1|neurite growth-promoting factor 1|osteoblast-specific factor 1|pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) |
Swissprots | Q9UCC6 Q5U0B0 Q6ICQ5 P21246 |
Accessions | AAB24425 AAB26456 EAL24052 EAW83869 EAW83870 EAW83871 EAW83872 P21246 AK290488 BAF83177 AK313424 BAG36216 AM392897 CAL37775 BC005916 AAH05916 BM968820 BT019692 AAV38498 CR450338 CAG29334 D90226 BAA14261 M57399 AAA35961 X52946 CAA37121 XM_005250515 XP_005250572 XM_005250516 XP_005250573 NM_002825 NP_002816 |
Function | Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:1768439}. |
Subcellular Location | Secreted. |
Tissue Specificity | Osteoblast and brain. |
Human Pleiotrophin full length protein - ab187227 from Abcam
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Human Pleiotrophin full length protein - ab73236 from Abcam
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Human Pleiotrophin protein fragment - ab50121 from Abcam
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PTN / Pleiotrophin Antibody Blocking Peptide - LS-E1530 from LifeSpan Bioscience
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PTN / Pleiotrophin Antibody Blocking Peptide - LS-E27156 from LifeSpan Bioscience
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Recombinant Human Pleiotrophin/PTN Protein - NBP2-35233 from Novus Biologicals
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Pleiotrophin/PTN Partial Recombinant Protein - H00005764-Q01 from Novus Biologicals
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Pleiotrophin/PTN Recombinant Protein - H00005764-P01 from Novus Biologicals
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Recombinant Human Pleiotrophin/PTN Protein - NBP1-99349 from Novus Biologicals
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PTN-Antibody-C-term-Blocking-peptide - BP12263b from Abgent, a WuXi AppTec company
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Pleiotrophin recombinant protein - GTX65228 from GeneTex
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Pleiotrophin Recombinant Protein - GTX48380-PRO from GeneTex
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Pleiotrophin blocking peptide - GTX88200-PEP from GeneTex
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Recombinant Human Pleiotrophin/PTN, CF - 252-PL-050 from R&D Systems
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Recombinant Human Pleiotrophin/PTN, CF - 252-PL-250 from R&D Systems
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Pleiotrophin Protein (OPPA00710) - OPPA00710 from Aviva Systems Biology
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Human PTN protein - orb223846 from Biorbyt
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Human Pleiotrophin protein - orb169039 from Biorbyt
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Human Pleiotrophin protein (Native) - orb139495 from Biorbyt
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Human Pleiotrophin protein - orb80551 from Biorbyt
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Human Pleiotrophin protein - orb169040 from Biorbyt
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PTN Immunizing peptide - orb59744 from Biorbyt
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Pleiotrophin Blocking Peptide - 33R-5246 from Fitzgerald
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Human Pleiotrophin Protein - abx068608 from Abbexa
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Pleiotrophin Peptide - AC21-1976-P from Abcore
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