MAPK8IP2

Gene Symbol MAPK8IP2
Entrez Gene 23542
Alt Symbol IB-2, IB2, JIP2, PRKM8IPL
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 8 interacting protein 2
Other Description C-Jun-amino-terminal kinase-interacting protein 2|JNK MAP kinase scaffold protein 2|JNK MAP kinase scaffold protein JIP2|JNK-interacting protein 2|homologous to mouse JIP-1|islet-brain 2
Swissprots Q9NZ59 Q9UKQ4 Q96G62 Q13387 Q99771
Accessions AAB03340 EAW73577 EAW73578 EAW73579 EAW73580 Q13387 AF136382 AAF00980 AF218778 AAF32323 AK293580 BAG57050 AK294265 BAG57558 AL021708 CAA16714 BC009940 AAH09940 BC037271 BC047527 AAH47527 BQ270598 BU732443 DB483256 EU832803 ACE87814 GQ129402 ACT64536 U79261 AAB50207 XM_011530679 XP_011528981 XM_011530680 XP_011528982 XM_011530681 XP_011528983 NM_012324 NP_036456 NM_016431 NM_139124
Function The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm. Note=Accumulates in cell surface projections.
Tissue Specificity Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.
Top Pathways MAPK signaling pathway

MAPK8IP2-Over-expression-Lysate - LY12049a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag MAPK8IP2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MAPK8IP2 gene

JIP-2 (h): 293T Lysate - sc-177412 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

JIP2 Overexpression Lysate (Native) - NBP2-10465 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: JIP2 Overexpression Lysate (Adult Normal) [NBP2-10465] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for JIP2.

Panoply™ Human MAPK8IP2 Knockdown Stable Cell Line - CSC-DC009207 from Creative biogene

Category Cell Line
Species Human
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