MAPK8IP2

Gene Symbol	MAPK8IP2
Entrez Gene	23542
Alt Symbol	IB-2, IB2, JIP2, PRKM8IPL
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 8 interacting protein 2
Other Description	C-Jun-amino-terminal kinase-interacting protein 2|JNK MAP kinase scaffold protein 2|JNK MAP kinase scaffold protein JIP2|JNK-interacting protein 2|homologous to mouse JIP-1|islet-brain 2
Swissprots	Q9NZ59 Q9UKQ4 Q96G62 Q13387 Q99771
Accessions	AAB03340 EAW73577 EAW73578 EAW73579 EAW73580 Q13387 AF136382 AAF00980 AF218778 AAF32323 AK293580 BAG57050 AK294265 BAG57558 AL021708 CAA16714 BC009940 AAH09940 BC037271 BC047527 AAH47527 BQ270598 BU732443 DB483256 EU832803 ACE87814 GQ129402 ACT64536 U79261 AAB50207 XM_011530679 XP_011528981 XM_011530680 XP_011528982 XM_011530681 XP_011528983 NM_012324 NP_036456 NM_016431 NM_139124
Function	The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm. Note=Accumulates in cell surface projections.
Tissue Specificity	Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JIP-2 (B-2) - sc-376065 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

JIP-2 (C-20) - sc-19740 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

JIP-2 (C-10) - sc-398926 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

JIP-2 (A-9) - sc-377490 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

JIP-2 (H-95) - sc-25549 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

JIP-2 (N-20) - sc-19738 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

JIP-2 (1E11) - sc-53553 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Anti-JIP2 antibody - ab65211 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-JIP2 antibody - ab154090 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JIP2 antibody [S135-37] - ab186280 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-JIP2 antibody [S135-37] (HRP) - ab186270 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-JIP2 antibody [S13537] (FITC) - ab186332 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S13537

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 488) - LS-C229299 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37) - LS-C209553 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 565) - LS-C229300 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 390) - LS-C229298 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 633) - LS-C229302 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 594) - LS-C229301 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 655) - LS-C229303 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 700) - LS-C229305 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Atto 680) - LS-C229304 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, APC) - LS-C229307 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, AP) - LS-C229306 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, Biotin) - LS-C229308 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

Anti-MAPK8IP2 / JIP2 Antibody (aa226-421, clone S135-37, FITC) - LS-C229309 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S135-37

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