| Gene Symbol | MAPK8IP2 |
|---|---|
| Entrez Gene | 23542 |
| Alt Symbol | IB-2, IB2, JIP2, PRKM8IPL |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase 8 interacting protein 2 |
| Other Description | C-Jun-amino-terminal kinase-interacting protein 2|JNK MAP kinase scaffold protein 2|JNK MAP kinase scaffold protein JIP2|JNK-interacting protein 2|homologous to mouse JIP-1|islet-brain 2 |
| Swissprots | Q9NZ59 Q9UKQ4 Q96G62 Q13387 Q99771 |
| Accessions | AAB03340 EAW73577 EAW73578 EAW73579 EAW73580 Q13387 AF136382 AAF00980 AF218778 AAF32323 AK293580 BAG57050 AK294265 BAG57558 AL021708 CAA16714 BC009940 AAH09940 BC037271 BC047527 AAH47527 BQ270598 BU732443 DB483256 EU832803 ACE87814 GQ129402 ACT64536 U79261 AAB50207 XM_011530679 XP_011528981 XM_011530680 XP_011528982 XM_011530681 XP_011528983 NM_012324 NP_036456 NM_016431 NM_139124 |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Note=Accumulates in cell surface projections. |
| Tissue Specificity | Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland. |
| Top Pathways | MAPK signaling pathway |
JIP-2 CRISPR/Cas9 KO Plasmid (h) - sc-403514 from Santa Cruz Biotechnology
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JIP-2 HDR Plasmid (h) - sc-403514-HDR from Santa Cruz Biotechnology
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JIP-2 Double Nickase Plasmid (h) - sc-403514-NIC from Santa Cruz Biotechnology
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JIP-2 Double Nickase Plasmid (h2) - sc-403514-NIC-2 from Santa Cruz Biotechnology
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JIP-2 CRISPR Activation Plasmid (h) - sc-403514-ACT from Santa Cruz Biotechnology
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JIP-2 CRISPR Activation Plasmid (h2) - sc-403514-ACT-2 from Santa Cruz Biotechnology
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JIP-2 Lentiviral Activation Particles (h) - sc-403514-LAC from Santa Cruz Biotechnology
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JIP-2 Lentiviral Activation Particles (h2) - sc-403514-LAC-2 from Santa Cruz Biotechnology
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JIP-2 siRNA (h) - sc-40719 from Santa Cruz Biotechnology
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JIP-2 shRNA Plasmid (h) - sc-40719-SH from Santa Cruz Biotechnology
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JIP-2 shRNA (h) Lentiviral Particles - sc-40719-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU135051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13017 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13017 from Sigma-Aldrich
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MAPK8IP2 siRNA (Human) - CRH8344 from Cohesion Biosciences
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shRNA set against Human MAPK8IP2 (NM_012324.3) - SHH338099 from Creative biogene
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shRNA set against Human MAPK8IP2(NM_016431.3) - SHH176051 from Creative biogene
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shRNA set against Human MAPK8IP2(NM_012324.3) - SHH176069 from Creative biogene
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MAPK8IP2 shRNA Plasmid (Human) - CHH8344 from Cohesion Biosciences
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MAPK8IP2 miRNA 3'UTR clone - MiUTR1H-06091 from Creative biogene
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MAPK8IP2 miRNA 3'UTR clone - MiUTR3H-09446 from Creative biogene
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