| Gene Symbol |
NABP1
|
| Entrez Gene |
64859
|
| Alt Symbol |
OBFC2A, SOSS-B2, SSB2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nucleic acid binding protein 1
|
| Other Description |
SOSS complex subunit B2|nucleic acid-binding protein 1|oligonucleotide/oligosaccharide-binding fold containing 2A|oligonucleotide/oligosaccharide-binding fold-containing protein 2A|sensor of single-strand DNA complex subunit B2|sensor of ssDNA subunit B2|single-stranded DNA-binding protein 2
|
| Swissprots |
Q9H5X6 Q96AH0 Q658Y8
|
| Accessions |
AAY24348 EAX10835 EAX10836 EAX10837 EAX10838 Q96AH0 AK023686 AK026486 BAB15491 AL832659 CAH56209 AL833684 BC017114 AAH17114 BC107723 AAI07724 BI553898 CA307622 DA026631 DB477793 HQ447964 ADQ32447 XR_922988 NM_022837 NM_001031716 NP_001026886 NM_001254736 NP_001241665 NR_045622 NR_045623
|
| Function |
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
|
