Gene Symbol | NABP1 |
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Entrez Gene | 64859 |
Alt Symbol | OBFC2A, SOSS-B2, SSB2 |
Species | Human |
Gene Type | protein-coding |
Description | nucleic acid binding protein 1 |
Other Description | SOSS complex subunit B2|nucleic acid-binding protein 1|oligonucleotide/oligosaccharide-binding fold containing 2A|oligonucleotide/oligosaccharide-binding fold-containing protein 2A|sensor of single-strand DNA complex subunit B2|sensor of ssDNA subunit B2|single-stranded DNA-binding protein 2 |
Swissprots | Q9H5X6 Q96AH0 Q658Y8 |
Accessions | AAY24348 EAX10835 EAX10836 EAX10837 EAX10838 Q96AH0 AK023686 AK026486 BAB15491 AL832659 CAH56209 AL833684 BC017114 AAH17114 BC107723 AAI07724 BI553898 CA307622 DA026631 DB477793 HQ447964 ADQ32447 XR_922988 NM_022837 NM_001031716 NP_001026886 NM_001254736 NP_001241665 NR_045622 NR_045623 |
Function | Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage. |
Human OBFC2A full length protein - ab171488 from Abcam
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OBFC2A protein (His-DHFR tag) - ab127660 from Abcam
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Recombinant Human OBFC2A Protein - H00064859-P01 from Novus Biologicals
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OBFC2A-Antibody-Center-Blocking-peptide - BP10286c from Abgent, a WuXi AppTec company
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Human NABP1 protein - orb244916 from Biorbyt
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Human NABP1 protein - orb191373 from Biorbyt
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NABP1 protein (His tag) - 80R-3486 from Fitzgerald
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OBFC2A (1-204, His-tag) - AR51177PU-N from Acris Antibodies
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OBFC2A (1-204, His-tag) - AR51177PU-S from Acris Antibodies
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OBFC2A - H00064859-P01-10 from Acris Antibodies
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OBFC2A - H00064859-P01-25 from Acris Antibodies
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NABP1, 1-204aa, Human, His tag, E.coli - 01-P2353 from ARP American Research Products
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OBFC2A fusion protein - Ag10383 from Proteintech Group
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OBFC2A fusion protein - Ag10158 from Proteintech Group
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Recombinant Human nucleic acid binding protein 1, His-tagged - NABP1-270H from Creative Biomart
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Recombinant Human NABP1 - NABP1-1123H from Creative Biomart
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Recombinant Human OBFC2A, His-tagged - OBFC2A-1436H from Creative Biomart
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Recombinant Human SOSS complex subunit B2(OBFC2A) - CSB-YP850257HU CSB-BP850257HU CSB-MP850257HU from Cusabio
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Recombinant human SOSS complex subunit B2 - CSB-EP850257HU from Cusabio
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NABP1, 1-204aa, Human, His tag, E.coli - ATGP2353 from ATGen
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OBFC2A (full length, N-term HIS tag, transcript variant 1) - TP760793 from Acris Antibodies
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NABP1 Peptide, Human - M34GP10090H from Creative Peptides
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NABP1 Recombinant Protein (OPCA02421) - OPCA02421 from Aviva Systems Biology
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NABP1 - PAT-82352-1 from Nordic BioSite
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NABP1 - PAT-82352-2 from Nordic BioSite
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