RELN

Gene Symbol	RELN
Entrez Gene	5649
Alt Symbol	LIS2, PRO1598, RL
Species	Human
Gene Type	protein-coding
Description	reelin
Other Description	-
Swissprots	A4D0Q0 Q86UJ0 Q8NDV0 Q9UDQ2 P78509 Q86UJ8 A4D0P9
Accessions	AAB46357 AAD29127 AAM49151 AAM51648 AAP22330 AAP22355 AAQ96860 AAS02019 CCQ43295 EAL24410 EAL24411 EAW83336 EAW83337 EAW83338 P78509 AK093843 AK293863 BAG57256 AK297459 BAG59882 AY927583 BC172269 AAI72269 U79716 AAC51105 NM_005045 NP_005036 NM_173054 NP_774959
Function	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). {ECO:0000250}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity	Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver. {ECO:0000269\|PubMed:9861036}.
Top Pathways	Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway

Reelin (E-5) - sc-25346 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Reelin (E-5): sc-25346. Immunoperoxidase staining of formalin fixed, paraffin-embedded human stomach tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

Reelin (K-15) - sc-32554 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Reelin (D-17) - sc-32556 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Reelin (H-221) - sc-5578 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Reelin (H-221): sc-5578. Western blot analysis of Reelin expression in mouse brain (A) and rat brain (B) tissue extracts.

Anti-Reelin antibody - ab138370 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

IHC image of Reelin staining in Mouse normal brain formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol B. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab138370, 1µg/ml, for 15 mins at room temperature. A Goat anti-Rabbit biotinylated secondary antibody was used to detect the primary, and visualized using an HRP conjugated ABC system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-Reelin antibody - ab193196 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunnohistochemical analysis of Formalin-fixed, paraffin-embedded mouse liver labeling Reelin with ab193196 at 1/100 dilution

Anti-Reelin antibody [EPR3330(2)] - ab139691 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR3330(2)

All lanes : Anti-Reelin antibody [EPR3330(2)] (ab139691) at 1/1000 dilutionLane 1 : HepG2 cell lysateLane 2 : C6 cell lysateLane 3 : Human fetal brain lysateLysates/proteins at 10 µg per lane.SecondaryStandard HRP labelled goat anti-rabbit at 1/2000 dilutiondeveloped using the ECL technique

Anti-Reelin antibody [G10] - ab78540 from Abcam

Prices	$385.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	G10

ab78540, at 1/1000 dilution staining Reelin in embryonic cerebral cortex at 15 days in utero, with the pial surface above and the ventricle below. The positive zone is the Cajal-Retzius cell layer in the marginal zone.

Anti-RELN / Reelin Antibody (aa40-189) - LS-C90872 from LifeSpan Bioscience

Prices	$530.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-RELN / Reelin Antibody (aa1221-2661) - LS-C38776 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (aa164-496) - LS-C90873 from LifeSpan Bioscience

Prices	$530.00
Sizes	50 µg
Host	Mouse
Clonality	Monoclonal

Anti-RELN / Reelin Antibody (aa27-861) - LS-C144135 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rat
Clonality	Monoclonal

Anti-RELN / Reelin Antibody (aa27-862) - LS-C150239 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Anti-RELN / Reelin Antibody - LS-C285596 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (aa2400-2610, Biotin) - LS-C299746 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (aa3143-3461, FITC) - LS-C303303 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (aa2400-2610, FITC) - LS-C303950 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (FITC) - LS-C317091 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (HRP) - LS-C317132 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (Biotin) - LS-C318818 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (clone RE-3B9(R3B9)) - LS-C179477 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	RE-3B9(R3B9)

Anti-RELN / Reelin Antibody (aa2398-2608) - LS-C314933 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant RELN / Reelin.

Anti-RELN / Reelin Antibody (aa3143-3461) - LS-C296196 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (aa2400-2610) - LS-C296197 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-RELN / Reelin Antibody (aa2400-2610) - LS-C314286 from LifeSpan Bioscience

Prices	$445.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal

Search more