| Gene Symbol |
RELN
|
| Entrez Gene |
5649
|
| Alt Symbol |
LIS2, PRO1598, RL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
reelin
|
| Other Description |
-
|
| Swissprots |
A4D0Q0 Q86UJ0 Q8NDV0 Q9UDQ2 P78509 Q86UJ8 A4D0P9
|
| Accessions |
AAB46357 AAD29127 AAM49151 AAM51648 AAP22330 AAP22355 AAQ96860 AAS02019 CCQ43295 EAL24410 EAL24411 EAW83336 EAW83337 EAW83338 P78509 AK093843 AK293863 BAG57256 AK297459 BAG59882 AY927583 BC172269 AAI72269 U79716 AAC51105 NM_005045 NP_005036 NM_173054 NP_774959
|
| Function |
Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Tissue Specificity |
Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver. {ECO:0000269|PubMed:9861036}.
|
| Top Pathways |
Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway
|