RELN

Gene Symbol	RELN
Entrez Gene	5649
Alt Symbol	LIS2, PRO1598, RL
Species	Human
Gene Type	protein-coding
Description	reelin
Other Description	-
Swissprots	A4D0Q0 Q86UJ0 Q8NDV0 Q9UDQ2 P78509 Q86UJ8 A4D0P9
Accessions	AAB46357 AAD29127 AAM49151 AAM51648 AAP22330 AAP22355 AAQ96860 AAS02019 CCQ43295 EAL24410 EAL24411 EAW83336 EAW83337 EAW83338 P78509 AK093843 AK293863 BAG57256 AK297459 BAG59882 AY927583 BC172269 AAI72269 U79716 AAC51105 NM_005045 NP_005036 NM_173054 NP_774959
Function	Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity). {ECO:0000250}.
Subcellular Location	Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity	Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver. {ECO:0000269|PubMed:9861036}.
Top Pathways	Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Recombinant Human Reelin, CF - 8546-MR-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Ser1221-Gln2666, with a C-terminal 6-His tag

Recombinant human Reelin (OPCA01295) - OPCA01295 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human RELN protein - orb245974 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human RELN protein - orb244491 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Recombinant Reelin (RL) - RPC775Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Hu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Hu03 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Hu04 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Reelin (RL) - RPC775Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Reelin (RL) - RPC775Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Reelin (RL) - RPC775Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Hu02 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Hu03 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Reelin (RL) - RPC775Hu04 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant human Reelin - CSB-EP019557HU CSB-BP019557HU CSB-MP019557HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Reelin(RELN) ,partial - CSB-YP019557HU CSB-BP019557HU CSB-MP019557HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Reelin(RELN) ,partial - CSB-EP019557HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Human Reelin Protein, CF - 8546-MR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Ser1221-Gln2666, with a C-terminal 6-His tag Species Human

Reelin Protein (Recombinant) - abx168086 from Abbexa Category Protein Source Human Species Human

Reelin Protein (Recombinant) - abx168084 from Abbexa Category Protein Source Human Species Human

Reelin Protein (Recombinant) - abx166548 from Abbexa Category Protein Source Human Species Human

Reelin Protein (Recombinant) - abx166547 from Abbexa Category Protein Source Human Species Human

Recombinant Human Reelin(RELN) ,partial - CSB-MP019557HU from Cusabio Category Protein Source Yeast Species Human

Recombinant Human Reelin(RELN) ,partial - CSB-BP019557HU from Cusabio Category Protein Source Yeast Species Human

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