| Gene Symbol |
EFNB3
|
| Entrez Gene |
1949
|
| Alt Symbol |
EFL6, EPLG8, LERK8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ephrin-B3
|
| Other Description |
EPH-related receptor transmembrane ligand ELK-L3|Ephrin B3|eph-related receptor tyrosine kinase ligand 8
|
| Swissprots |
O00680 Q15768 Q8TBH7 D3DTQ6 Q92875 B2RBW2
|
| Accessions |
EAW90133 EAW90134 EAW90135 Q15768 AI346983 AK027329 AK314841 BAG37359 BC022499 AAH22499 BC042944 AAH42944 BQ892951 U57001 AAB05170 U62775 AAC50707 U66406 AAC51203 NM_001406 NP_001397
|
| Function |
Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.
|
| Top Pathways |
Axon guidance
|