| Gene Symbol |
DDRGK1
|
| Entrez Gene |
65992
|
| Alt Symbol |
C20orf116, UFBP1, dJ1187M17.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DDRGK domain containing 1
|
| Other Description |
DDRGK domain-containing protein 1|Dashurin|UFM1-binding and PCI domain-containing protein 1|UFM1-binding protein 1 containing a PCI domain
|
| Swissprots |
C9JSZ5 Q96HY6 A6NIU5 Q9BW47
|
| Accessions |
EAX10543 EAX10544 Q96HY6 AF086090 AK310809 BC000643 AAH00643 BC007957 AAH07957 BC011851 AAH11851 HQ448262 ADQ32742 NM_023935 NP_076424
|
| Function |
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498}.
|
| Subcellular Location |
Endoplasmic reticulum {ECO:0000269|PubMed:20018847}.
|
| Tissue Specificity |
Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:20018847}.
|
![Western Blot: DDRGK1 Overexpression Lysate (Adult Normal) [NBL1-08360] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DDRGK1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3822_DDRGK1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08360-img0002.jpg)