Gene Symbol | DDRGK1 |
---|---|
Entrez Gene | 65992 |
Alt Symbol | C20orf116, UFBP1, dJ1187M17.3 |
Species | Human |
Gene Type | protein-coding |
Description | DDRGK domain containing 1 |
Other Description | DDRGK domain-containing protein 1|Dashurin|UFM1-binding and PCI domain-containing protein 1|UFM1-binding protein 1 containing a PCI domain |
Swissprots | C9JSZ5 Q96HY6 A6NIU5 Q9BW47 |
Accessions | EAX10543 EAX10544 Q96HY6 AF086090 AK310809 BC000643 AAH00643 BC007957 AAH07957 BC011851 AAH11851 HQ448262 ADQ32742 NM_023935 NP_076424 |
Function | Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:20018847}. |
Tissue Specificity | Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:20018847}. |