Gene Symbol | DDRGK1 |
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Entrez Gene | 65992 |
Alt Symbol | C20orf116, UFBP1, dJ1187M17.3 |
Species | Human |
Gene Type | protein-coding |
Description | DDRGK domain containing 1 |
Other Description | DDRGK domain-containing protein 1|Dashurin|UFM1-binding and PCI domain-containing protein 1|UFM1-binding protein 1 containing a PCI domain |
Swissprots | C9JSZ5 Q96HY6 A6NIU5 Q9BW47 |
Accessions | EAX10543 EAX10544 Q96HY6 AF086090 AK310809 BC000643 AAH00643 BC007957 AAH07957 BC011851 AAH11851 HQ448262 ADQ32742 NM_023935 NP_076424 |
Function | Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription (PubMed:25219498). May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIB, the inhibitor of NF-kappa-B (PubMed:23675531). May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q80WW9, ECO:0000269|PubMed:23675531, ECO:0000269|PubMed:25219498}. |
Subcellular Location | Endoplasmic reticulum {ECO:0000269|PubMed:20018847}. |
Tissue Specificity | Ubiquitously expressed (at protein level). {ECO:0000269|PubMed:20018847}. |
DDRGK1 CRISPR/Cas9 KO Plasmid (h) - sc-413090 from Santa Cruz Biotechnology
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DDRGK1 HDR Plasmid (h) - sc-413090-HDR from Santa Cruz Biotechnology
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DDRGK1 Double Nickase Plasmid (h) - sc-413090-NIC from Santa Cruz Biotechnology
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DDRGK1 Double Nickase Plasmid (h2) - sc-413090-NIC-2 from Santa Cruz Biotechnology
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DDRGK1 CRISPR Activation Plasmid (h) - sc-413090-ACT from Santa Cruz Biotechnology
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DDRGK1 CRISPR Activation Plasmid (h2) - sc-413090-ACT-2 from Santa Cruz Biotechnology
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DDRGK1 Lentiviral Activation Particles (h) - sc-413090-LAC from Santa Cruz Biotechnology
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DDRGK1 Lentiviral Activation Particles (h2) - sc-413090-LAC-2 from Santa Cruz Biotechnology
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DDRGK1 siRNA (h) - sc-72698 from Santa Cruz Biotechnology
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DDRGK1 shRNA Plasmid (h) - sc-72698-SH from Santa Cruz Biotechnology
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DDRGK1 shRNA (h) Lentiviral Particles - sc-72698-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU059871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7032 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7032 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02096 from Sigma-Aldrich
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DDRGK1 siRNA (Human) - CRJ2219 from Cohesion Biosciences
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DDRGK1 - MBS8222694 from MyBioSource
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shRNA set against Human DDRGK1 (NM_023935.1) - SHH275749 from Creative biogene
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Human DDRGK1 siRNA - orb272720 from Biorbyt
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DDRGK1 shRNA Plasmid (Human) - CHJ2219 from Cohesion Biosciences
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DDRGK1 miRNA 3'UTR clone - MiUTR1H-01301 from Creative biogene
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