| Gene Symbol |
DENND6A
|
| Entrez Gene |
201627
|
| Alt Symbol |
AFI1A, FAM116A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DENN/MADD domain containing 6A
|
| Other Description |
DENN domain-containing protein 6A|family with sequence similarity 116, member A|protein DENND6A|protein FAM116A
|
| Swissprots |
Q8N235 Q8IWF6 Q8TEG8 Q7Z5T4
|
| Accessions |
EAW65345 EAW65346 Q8IWF6 AA605125 AK074156 BAB84982 AK092288 BAC03852 BC040291 AAH40291 BC054343 AAH54343 DB163127 JF432855 ADZ16072 XM_006713019 XP_006713082 XM_006713020 XP_006713083 XM_011533476 XP_011531778 XR_245100 NM_152678 NP_689891
|
| Function |
Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes. {ECO:0000269|PubMed:22595670}.
|
| Subcellular Location |
Recycling endosome {ECO:0000269|PubMed:22595670}. Cytoplasm {ECO:0000269|PubMed:22595670}.
|
![Western Blot: FAM116A Overexpression Lysate (Adult Normal) [NBL1-10451] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FAM116A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3250_FAM116A%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10451-img0002.jpg)